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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Hospital outbreak of middle east respiratory syndrome coronavirus
New England Journal of Medicine, Volume 369, No. 5, Year 2013
Notification
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Description
BACKGROUND: In September 2012, the World Health Organization reported the first cases of pneumonia caused by the novel Middle East respiratory syndrome coronavirus (MERSCoV). We describe a cluster of health care-acquired MERS-CoV infections. METHODS: Medical records were reviewed for clinical and demographic information and determination of potential contacts and exposures. Case patients and contacts were interviewed. The incubation period and serial interval (the time between the successive onset of symptoms in a chain of transmission) were estimated. Viral RNA was sequenced. RESULTS: Between April 1 and May 23, 2013, a total of 23 cases of MERS-CoV infection were reported in the eastern province of Saudi Arabia. Symptoms included fever in 20 patients (87%), cough in 20 (87%), shortness of breath in 11 (48%), and gastrointestinal symptoms in 8 (35%); 20 patients (87%) presented with abnormal chest radiographs. As of June 12, a total of 15 patients (65%) had died, 6 (26%) had recovered, and 2 (9%) remained hospitalized. The median incubation period was 5.2 days (95% confidence interval [CI], 1.9 to 14.7), and the serial interval was 7.6 days (95% CI, 2.5 to 23.1). A total of 21 of the 23 cases were acquired by person-to-person transmission in hemodialysis units, intensive care units, or in-patient units in three different health care facilities. Sequencing data from four isolates revealed a single monophyletic clade. Among 217 household contacts and more than 200 health care worker contacts whom we identified, MERS-CoV infection developed in 5 family members (3 with laboratory-confirmed cases) and in 2 health care workers (both with laboratory-confirmed cases). CONCLUSIONS: Person-to-person transmission of MERS-CoV can occur in health care settings and may be associated with considerable morbidity. Surveillance and infection-control measures are critical to a global public health response. Copyright © 2013 Massachusetts Medical Society.
Authors & Co-Authors
Asiri, Abdullah M.
Saudi Arabia, Riyadh
Ministry of Health Saudi Arabia
Mcgeer, Allison J.
Canada, Toronto
University of Toronto
Perl, Trish M.
United States, Baltimore
Johns Hopkins University
Price, Connie S.
United States, Denver
University of Colorado Denver
Al-Rabeeah, Abdullah A.
Saudi Arabia, Riyadh
Ministry of Health Saudi Arabia
Cummings, Derek A.T.
United States, Baltimore
Johns Hopkins University
Alabdullatif, Zaki N.
Saudi Arabia, Riyadh
Ministry of Health Saudi Arabia
Assad, Maher
Saudi Arabia, Riyadh
Ministry of Health Saudi Arabia
Almulhim, Abdulmohsen
Saudi Arabia, Riyadh
Ministry of Health Saudi Arabia
Makhdoom, Hatem Q.
Saudi Arabia, Riyadh
Ministry of Health Saudi Arabia
Madani, Hossam
Saudi Arabia, Riyadh
Ministry of Health Saudi Arabia
AlHakeem, Rafat F.
Saudi Arabia, Riyadh
Ministry of Health Saudi Arabia
Al-Tawfiq, Jaffar Ali
Saudi Arabia, Dhahran
Johns Hopkins Aramco Healthcare
Cotten, Matt
United Kingdom, Hinxton
Wellcome Sanger Institute
Watson, Simon James
United Kingdom, Hinxton
Wellcome Sanger Institute
Kellam, P.
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, London
University College London
Zumla, A. I.
Saudi Arabia, Riyadh
Ministry of Health Saudi Arabia
United Kingdom, London
University College London
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
Al Memish, Ziad Ahmed
Saudi Arabia, Riyadh
Ministry of Health Saudi Arabia
Saudi Arabia, Riyadh
Alfaisal University
Statistics
Citations: 1,164
Authors: 18
Affiliations: 9
Identifiers
Doi:
10.1056/NEJMoa1306742
ISSN:
00284793
e-ISSN:
15334406
Research Areas
Covid
Health System And Policy