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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Long term conservation of human metabolic phenotypes and link to heritability
Metabolomics, Volume 10, No. 5, Year 2014
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Description
Changes in an individual's human metabolic phenotype (metabotype) over time can be indicative of disorder-related modifications. Studies covering several months to a few years have shown that metabolic profiles are often specific for an individual. This "metabolic individuality" and detected changes may contribute to personalized approaches in human health care. However, it is not clear whether such individual metabotypes persist over longer time periods. Here we investigate the conservation of metabotypes characterized by 212 different metabolites of 818 participants from the Cooperative Health Research in the Region of Augsburg; Germany population, taken within a 7-year time interval. For replication, we used paired samples from 83 non-related individuals from the TwinsUK study. Results indicated that over 40 % of all study participants could be uniquely identified after 7 years based on their metabolic profiles alone. Moreover, 95 % of the study participants showed a high degree of metabotype conservation (>70 %) whereas the remaining 5 % displayed major changes in their metabolic profiles over time. These latter individuals were likely to have undergone important biochemical changes between the two time points. We further show that metabolite conservation was positively associated with heritability (rank correlation 0.74), although there were some notable exceptions. Our results suggest that monitoring changes in metabotypes over several years can trace changes in health status and may provide indications for disease onset. Moreover, our study findings provide a general reference for metabotype conservation over longer time periods that can be used in biomarker discovery studies. © 2014 The Author(s).
Available Materials
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Authors & Co-Authors
Yousri, Noha A.
Qatar, Doha
Weill Cornell Medicine-qatar
Egypt, Alexandria
Faculty of Engineering
Kastenmüller, Gabi
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Gieger, Christian
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Shin, So-youn
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, Bristol
University of Bristol
Erte, Idil
United Kingdom, London
King's College London
Menni, Cristina
United Kingdom, London
King's College London
Peters, Annette Michael
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Meisinger, Christa
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Mohney, Robert P.
United States, Morrisville
Metabolon, Inc.
Illig, Thomas
Germany, Hannover
Hannover Medical School
Adamski, Jerzy
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Soranzo, Nicole
United Kingdom, Hinxton
Wellcome Sanger Institute
Spector, Tim David
United Kingdom, London
King's College London
Suhre, Karsten
Qatar, Doha
Weill Cornell Medicine-qatar
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Statistics
Citations: 14
Authors: 14
Affiliations: 8
Identifiers
Doi:
10.1007/s11306-014-0629-y
ISSN:
15733882
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study