Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Usefulness of Peak Troponin-T to Predict Infarct Size and Long-Term Outcome in Patients With First Acute Myocardial Infarction After Primary Percutaneous Coronary Intervention
American Journal of Cardiology, Volume 103, No. 6, Year 2009
Notification
URL copied to clipboard!
Description
In acute myocardial infarction cardiac troponin-T (cTnT) is the preferred biomarker to detect myocardial necrosis. Our aim was to investigate the prognostic value of peak plasma cTnT in patients with ST-elevation myocardial infarction treated by primary percutaneous coronary intervention (PCI). Patients were eligible if ST-elevation myocardial infarction symptoms started <9 hours before the primary PCI. During the first 48 hours after primary PCI, cTnT and creatine kinase were measured repeatedly. Main outcome measures were left ventricular ejection fraction assessed by myocardial scintigraphy at 90 days, and clinical outcomes through 1-year follow-up after primary PCI in a dedicated outpatient clinic; 168 consecutive patients (79% men) with first ST-elevation myocardial infarction were studied. Mean age ± SD was 59 ± 12 years. Peak cTnT values were reached within 24 hours after primary PCI in all patients. The enzymatic infarct size, measured by cumulative 48-hours creatine kinase release, correlated positively with peak cTnT (r = 0.73, p <0.001). Left ventricular ejection fraction at 3 months was negatively correlated with peak cTnT (r = -0.52, p <0.001). A peak plasma cTnT ≥6.5 μg/L predicted a left ventricular ejection fraction ≤40% at follow-up with 86% sensitivity and 74% specificity. Multivariable Cox regression analysis identified peak cTnT as an independent predictor of major adverse cardiac events (hazard ratio 1.07, 95% confidence limits 1.01 to 1.12) and heart failure (hazard ratio 1.12, 95% confidence limits 1.05 to 1.20) during follow-up. In conclusion, peak cTnT after primary PCI for ST-elevation myocardial infarction offers a good estimation of infarct size and is a prognostic indicator in patients with first acute myocardial infarction. © 2009 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Hassan, Ayman K.M.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Egypt, Asyut
Assiut University
Bergheanu, Sandrin C.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Hasan-Ali, Hosam
Netherlands, Leiden
Leids Universitair Medisch Centrum
Egypt, Asyut
Assiut University
Liem, Su San
Netherlands, Leiden
Leids Universitair Medisch Centrum
Van Der Laarse, Arnoud
Netherlands, Leiden
Leids Universitair Medisch Centrum
Wolterbeek, Ron
Netherlands, Leiden
Leids Universitair Medisch Centrum
Atsma, Douwe E.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Schalij, Martin Jan
Netherlands, Leiden
Leids Universitair Medisch Centrum
Jukema, Johan Wouter
Netherlands, Leiden
Leids Universitair Medisch Centrum
Statistics
Citations: 71
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1016/j.amjcard.2008.11.031
ISSN:
00029149
Research Areas
Environmental
Health System And Policy
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cohort Study
Study Approach
Quantitative
Participants Gender
Male