Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia
Molecular Psychiatry, Volume 12, No. 12, Year 2007
Notification
URL copied to clipboard!
Description
Left-right asymmetrical brain function underlies much of human cognition, behavior and emotion. Abnormalities of cerebral asymmetry are associated with schizophrenia and other neuropsychiatric disorders. The molecular, developmental and evolutionary origins of human brain asymmetry are unknown. We found significant association of a haplotype upstream of the gene LRRTM1 (Leucine-rich repeat transmembrane neuronal 1) with a quantitative measure of human handedness in a set of dyslexic siblings, when the haplotype was inherited paternally (P=0.00002). While we were unable to find this effect in an epidemiological set of twin-based sibships, we did find that the same haplotype is overtransmitted paternally to individuals with schizophrenia/schizoaffective disorder in a study of 1002 affected families (P=0.0014). We then found direct confirmatory evidence that LRRTM1 is an imprinted gene in humans that shows a variable pattern of maternal downregulation. We also showed that LRRTM1 is expressed during the development of specific forebrain structures, and thus could influence neuronal differentiation and connectivity. This is the first potential genetic influence on human handedness to be identified, and the first putative genetic effect on variability in human brain asymmetry. LRRTM1 is a candidate gene for involvement in several common neurodevelopmental disorders, and may have played a role in human cognitive and behavioral evolution. ©2007 Nature Publishing Group All rights reserved.
Authors & Co-Authors
Francks, Clyde
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Italy, Verona
Glaxosmithkline Spa
Maegawa, S.
Japan, Tottori
Tottori University
Laurén, J.
United States, New Haven
Yale School of Medicine
Abrahams, B. S.
United States, Los Angeles
David Geffen School of Medicine at Ucla
Velayos-Baeza, A.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Medland, Sarah E.
United States, Richmond
Virginia Institute for Psychiatric and Behavioral Genetics
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Colella, S.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Groszer, M.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
McAuley, E. Z.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Caffrey, T. M.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Timmusk, T.
Estonia, Tallinn
Tallinna Tehnikaülikool
Pruunsild, P.
Estonia, Tallinn
Tallinna Tehnikaülikool
Koppel, I.
Estonia, Tallinn
Tallinna Tehnikaülikool
Lind, Penelope A.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Matsumoto-Itaba, N.
Japan, Yonago
Graduate School of Medical Sciences
Nicod, Jérôme
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Xiong, Lan
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Joober, Ridha
Canada, Montreal
Le Centre de Recherche Douglas
Enard, W.
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Krinsky, B.
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Nanba, E.
Japan, Tottori
Tottori University
Richardson, A. J.
United Kingdom, Oxford
University of Oxford
Riley, Brien P.
United States, Los Angeles
David Geffen School of Medicine at Ucla
Martin, Nicholas G.
United States, Richmond
Virginia Institute for Psychiatric and Behavioral Genetics
Strittmatter, Stephen M.
United States, New Haven
Yale School of Medicine
Möller, Hans Jürgen
Germany, Munich
Klinikum Der Universität München
Rujescu, Dan
Germany, Munich
Klinikum Der Universität München
St-Clair, David M.
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Muglia, P.
Italy, Verona
Glaxosmithkline Spa
Roos, J. L.
South Africa, Pretoria
University of Pretoria
Fisher, Simon E.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Wade-Martins, Richard
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Rouleau, Guy Armand
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
John F. Stein, John Frederick
United Kingdom, Oxford
University of Oxford
Karayiorgou, Maria
United States, New York
Rockefeller University
Geschwind, Daniel H.
United States, Los Angeles
David Geffen School of Medicine at Ucla
Ragoussis, Ioannis
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Kendler, Kenneth S.
United States, Los Angeles
David Geffen School of Medicine at Ucla
Airaksinen, M. S.
Finland, Helsinki
Helsingin Yliopisto
Oshimura, M.
Japan, Yonago
Graduate School of Medical Sciences
DeLisi, Lynn Eleanor
United States, New York
New York University
United States, Orangeburg
Nathan S. Kline Institute for Psychiatric Research
Monaco, A. P.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Statistics
Citations: 338
Authors: 42
Affiliations: 20
Identifiers
Doi:
10.1038/sj.mp.4002053
ISSN:
13594184
e-ISSN:
14765578
Research Areas
Genetics And Genomics
Maternal And Child Health
Mental Health
Study Approach
Quantitative