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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Predictors of contrast-induced nephropathy in chronic total occlusion percutaneous coronary intervention
EuroIntervention, Volume 9, No. 10, Year 2014
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Description
Aims: Contrast-induced nephropathy (CIN) is a leading cause of morbidity and mortality in patients undergoing percutaneous coronary intervention (PCI). Limited data, however, are available on predictors of CIN in PCI for chronic total occlusion (CTO) lesions. The aim of the study was to determine the risk of developing CIN in patients undergoing CTO PCI by studying the effects of clinical variables, interventional techniques, and CTO lesion characteristics on renal function. Methods and results: This retrospective analysis included consecutive patients referred for CTO PCI between January 2002 and December 2009. CIN was defined as an elevated serum creatinine level ≥25% of baseline serum creatinine level at 48-72 hours after procedure. Patient characteristics, Mehran score, lesion characteristics, interventional procedure, and devices used were compared between CIN and non-CIN groups. For the 516 patients eligible for analysis, the incidence of CIN was 5.4% (28/516). Two patients needed transient haemodialysis (0.4%, 2/516). Analysis of risk using Mehran scoring found that the incidence of CIN was 0.5% (1/207) among low-risk patients, 3.4% (7/205) among moderate-risk patients, 15.9% (14/88) among high-risk patients and 37.5% (6/16) among very high-risk patients. The Mehran score high-risk group (11-15) and the very high-risk group (≥16) were definitely predictors of CIN after CTO PCI (OR: 27.022 [95% CI: 2.787-262.028, p=0.004]; OR: 32.512 [95% CI: 2.149-491.978, p=0.012]). Severe tortuosity was the only predictor of CIN after CTO PCI in angiographic and procedural findings (OR: 6.621 [95% CI: 1.090-40.227, p=0.040]). Conclusions: Being in the Mehran score high-risk group (11-15) or the very high-risk group (≥16) and severe tortuosity were predictors of CIN after CTO PCI. © Europa Digital & Publishing 2014. All rights reserved.
Authors & Co-Authors
Lin, Yu Sheng
Taiwan, Taipei
Chang Gung Memorial Hospital
Taiwan, Taoyuan
Chang Gung University of Science and Technology
Fang, Hsiuyu
Taiwan, Taoyuan
Chang Gung University College of Medicine
Hussein, Hesham
Egypt, Cairo
National Heart Institute
Fang, Chih Yuan
Taiwan, Taoyuan
Chang Gung University College of Medicine
Chen, Yunglung
Taiwan, Taoyuan
Chang Gung University College of Medicine
Hsueh, Shukai
Taiwan, Taoyuan
Chang Gung University College of Medicine
Cheng, Cheng I.
Taiwan, Taoyuan
Chang Gung University College of Medicine
Yang, Chenghsu
Taiwan, Taoyuan
Chang Gung University College of Medicine
Chen, Chien Jen
Taiwan, Taoyuan
Chang Gung University College of Medicine
Hang, Chiling
Taiwan, Taoyuan
Chang Gung University College of Medicine
Yip, Hon Kan
Taiwan, Taoyuan
Chang Gung University College of Medicine
Wu, Chiungjen
Taiwan, Taoyuan
Chang Gung University College of Medicine
Statistics
Citations: 31
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.4244/EIJV9I10A198
ISSN:
1774024X
e-ISSN:
19696213
Research Areas
Health System And Policy
Study Design
Randomised Control Trial
Cohort Study