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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Abu Dhabi third stage trial: oxytocin versus Syntometrine in the active management of the third stage of labour
European Journal of Obstetrics and Gynecology and Reproductive Biology, Volume 58, No. 2, Year 1995
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Description
Objective: To compare the effect of oxytocin and Syntometrine when used as part of active management of third stage of labour on postpartum haemorrhage, hypertension, nausea/vomiting and retained placenta. Study design: A randomised double blind trial was conducted in the Obstetric Unit of Corniche Hospital, Abu Dhabi in the United Arab Emirates. Between 1 January 1991 and 30 June 1991, 2040 women were randomly allocated either to the oxytocin (n = 1017) or the Syntometrine (n = 1023) group. Twelve patients had to be excluded from the trial (oxytocin, 5; Syntometrine, 7) after randomisation because they no longer fulfilled the inclusion criteria. All women in the trial received either oxytocin 10 units or Syntometrine 1 ml (oxytocin 5 units + ergometrine (ergonovine) 0.5 mg) by intramuscular injection with delivery of the anterior shoulder of the baby. Relative risk with 95% confidence intervals was calculated for each variable. Results: Oxytocin (10 units) alone was as effective as Syntometrine (1 ml) in preventing post-partum haemorrhage without an increase in the incidence of retained placenta. Median blood loss was similar in both groups. The incidences of nausea, vomiting and headache were significantly lower in the oxytocin group, as was the occurrence of a mean rise in diastolic and systolic blood pressures of 20 and 30 mmHg or more, respectively. Conclusion: Prophylactic administration of oxytocin 10 U in the third stage of labour, as part of active management, reduces the incidence of maternal nausea, vomiting, headache and rise in blood pressure than does Syntometrine 1 ml without adversely affecting the rate of post partum haemorrhage. © 1995.
Authors & Co-Authors
Khan, G. Quadir
United Arab Emirates, Abu Dhabi
Corniche Hospital
John, I. Susheela
United Arab Emirates, Abu Dhabi
Corniche Hospital
Chan, Teresa
United Arab Emirates, Abu Dhabi
Corniche Hospital
Wani, Salima
United Arab Emirates, Abu Dhabi
Corniche Hospital
Hughes, A. O.
United Kingdom, Bristol
University of Bristol
Stirrat, Gordon M.
United Kingdom, Bristol
University of Bristol
Statistics
Citations: 34
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/0028-2243(95)80014-J
ISSN:
00282243
Research Areas
Disability
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cohort Study
Participants Gender
Female