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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The additional prognostic power of diabetes mellitus on coronary flow reserve in patients with suspected coronary artery disease
Diabetes Research and Clinical Practice, Volume 78, No. 1, Year 2007
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Description
Aims: The aim of the present study was to assess the relative prognostic value of coronary flow reserve (CFR) and diabetes mellitus (DM) in patients with suspected coronary artery disease (CAD). Methods: We prospectively studied 347 inhospital patients with chest pain. Coronary angiography was performed in 281 patients (81%). All patients underwent a transthoracic echocardiographic study to evaluate left ventricular function and a stress vasodilator transoesophageal echocardiographic study to evaluate simultaneously CFR and the degree of aortic atherosclerosis (AA). The primary outcome of the study was cardiovascular mortality. Results: During a mean follow-up of 41 ± 12 months, 22 patients suffered cardiovascular death. Diabetic patients had a significantly higher AA grade and tended to have a lower CFR and more often significant CAD. Patients with normal CFR had less often significant CAD and tended to have less often DM. Significant univariable predictors of cardiovascular survival were DM, LV end-diastolic diameter, CFR and AA grade. Multivariable regression analysis showed that only CFR (hazard ratio (HR) 2.9, P = 0.01) and diabetes (HR 3.1, P = 0.01) were independent predictors of cardiovascular survival. Conclusions: CFR and DM evaluations offer complementary information during vasodilator stress TEE testing. Patients with reduced CFR (impaired microcirculatory function) and DM have the worst prognosis. © 2007 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Nemes, Attila
Hungary, Szeged
Szegedi Tudományegyetem Általános Orvostudományi Kar
Netherlands, Rotterdam
Erasmus Mc
Forster, Tamás
Hungary, Szeged
Szegedi Tudományegyetem Általános Orvostudományi Kar
Geleijnse, Marcel L.
Netherlands, Rotterdam
Erasmus Mc
Kutyifa, Valentina
Hungary, Szeged
Szegedi Tudományegyetem Általános Orvostudományi Kar
Neu, Klára
Hungary, Szeged
Szegedi Tudományegyetem Általános Orvostudományi Kar
Soliman, O. I.I.
Netherlands, Rotterdam
Erasmus Mc
Egypt, El-darrasa
El-hussein University Hospital
Ten Cate, Folkert J.
Netherlands, Rotterdam
Erasmus Mc
Csanády, Miklós
Hungary, Szeged
Szegedi Tudományegyetem Általános Orvostudományi Kar
Statistics
Citations: 26
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/j.diabres.2007.03.002
ISSN:
01688227
Research Areas
Environmental
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Quantitative