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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Antibody response against saliva antigens of Anopheles gambiae and Aedes aegypti in travellers in tropical Africa
Microbes and Infection, Volume 9, No. 12-13, Year 2007
Notification
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Description
Exposure to vectors of infectious diseases has been associated with antibody responses against salivary antigens of arthropods among people living in endemic areas. This immune response has been proposed as a surrogate marker of exposure to vectors appropriate for evaluating the protective efficacy of antivectorial devices. The existence and potential use of such antibody responses in travellers transiently exposed to Plasmodium or arbovirus vectors in tropical areas has never been investigated. The IgM and IgG antibody responses of 88 French soldiers against the saliva of Anopheles gambiae and Aedes aegypti were evaluated before and after a 5-month journey in tropical Africa. Antibody responses against Anopheles and Aedes saliva increased significantly in 41% and 15% of the individuals, respectively, and appeared to be specific to the mosquito genus. A proteomic and immunoproteomic analysis of anopheles and Aedes saliva allowed for the identification of some antigens that were recognized by most of the exposed individuals. These results suggest that antibody responses to the saliva of mosquitoes could be considered as specific surrogate markers of exposure of travellers to mosquito vectors that transmit arthropod borne infections. © 2007 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Orlandi-Pradines, Ève
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
France, Marseille
Institut Fédératif de la Recherche 48
Alméras, Lionel
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
France, Marseille
Institut Fédératif de la Recherche 48
Denis de Senneville, Laure
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
France, Marseille
Institut Fédératif de la Recherche 48
Barbe, Solenne
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
France, Marseille
Institut Fédératif de la Recherche 48
Remoue, Franck
Senegal, Dakar
Centre Ird de Hann
Villard, Claude
France, Marseille
Aix Marseille Université
Cornélie, Sylvie
Senegal, Dakar
Centre Ird de Hann
Penhoat, Kristell
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
France, Marseille
Institut Fédératif de la Recherche 48
Pascual, Aurélie M.
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
France, Marseille
Institut Fédératif de la Recherche 48
Bourgouin, Catherine
France, Paris
Institut Pasteur, Paris
Fontenille, Didier
France, Montpellier
Ird Centre de Montpellier
Bonnet, Julien
France, Montpellier
Ird Centre de Montpellier
Corre-Catelin, Nicole
France, Paris
Institut Pasteur, Paris
Reiter, Paul
France, Paris
Institut Pasteur, Paris
Pagés, Frédéric
France, Marseille
Institut Fédératif de la Recherche 48
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Laffite, Daniel
France, Marseille
Aix Marseille Université
Boulanger, Denis
Senegal, Dakar
Centre Ird de Hann
Simondon, François
Senegal, Dakar
Centre Ird de Hann
Pradines, Bruno
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
France, Marseille
Institut Fédératif de la Recherche 48
Fusaï, Thierry
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
France, Marseille
Institut Fédératif de la Recherche 48
Rogier, Christophe
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
France, Marseille
Institut Fédératif de la Recherche 48
Statistics
Citations: 107
Authors: 21
Affiliations: 6
Identifiers
Doi:
10.1016/j.micinf.2007.07.012
ISSN:
12864579
e-ISSN:
1769714X