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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Immune evasion activities of accessory proteins Vpu, Nef and Vif are conserved in acute and chronic HIV-1 infection
Virology, Volume 482, Year 2015
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Description
Heterosexual HIV-1 transmission has been identified as a genetic bottleneck and a single transmitted/founder (T/F) variant with reduced sensitivity to type I interferon initiates productive infection in most cases. We hypothesized that particularly active accessory protein(s) may confer T/F viruses with a selective advantage in establishing HIV infection. Thus, we tested vpu, vif and nef alleles from six T/F and six chronic (CC) viruses in assays for 9 immune evasion activities involving the counteraction of interferon-stimulated genes and modulation of ligands known to activate innate immune cells. All functions were highly conserved with no significant differences between T/F and CC viruses, suggesting that these accessory protein functions are important throughout the course of infection. © 2015 The Authors.
Authors & Co-Authors
Mlčochová, Petra
United Kingdom, London
University College London
Kirchhoff, Frank
Germany, Ulm
Universitätsklinikum Ulm
Malim, Michael H.
United Kingdom, London
King's College London
Sauter, Daniel
Germany, Ulm
Universitätsklinikum Ulm
Gupta, Ravindra K.
United Kingdom, London
University College London
Statistics
Citations: 13
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.virol.2015.03.015
ISSN:
00426822
Research Areas
Genetics And Genomics
Infectious Diseases