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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Identification of L-amino acid oxidase (Mb-LAAO) with antibacterial activity in the venom of Montivipera bornmuelleri, a viper from Lebanon
Infectious Disorders - Drug Targets, Volume 13, No. 5, Year 2013
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Description
The L-amino acid oxidase (LAAO) is a multifunctional enzyme, able to partake in different activities including antibacterial activity. In this study, a novel LAAO (Mb-LAAO) was isolated from the venom of M. bornmuelleri snake using size exclusion chromatography followed by RP-HPLC and partially characterized. However, the molecular weight of the Mb-LAAO determined by ESI-MS and SDS-PAGE was 59 960.4 Da. Once the enzymatic activity test confirming the enzyme's identity (transformation of L-leucine) was done, the Mb-LAAO was evaluated for its antibacterial activity against Gram-negative bacteria. It showed a remarkable effect against M. morganii and K. pneumoniae. Moreover, no cy-totoxic activity was observed for Mb-LAAO against human erythrocytes arguing for an exploration of its pharmaceutical interest. © 2013 Bentham Science Publishers.
Authors & Co-Authors
Rima, Mohamad
Lebanon, Beirut
Université Libanaise
Accary, Claudine
Lebanon, Beirut
Université Libanaise
Haddad, Katia
Lebanon, Beirut
Université Libanaise
Sadek, Riyad A.
Lebanon, Beirut
American University of Beirut
Hraoui-Bloquet, Souad
Lebanon, Beirut
Université Libanaise
Bidon-Defontis, Jean Claude
France, Nantes
Oniris - Ecole Nationale Vétérinaire, Agroalimentaire et de L’alimentation
Fajloun, Ziad
Lebanon, Beirut
Université Libanaise
Statistics
Citations: 12
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.2174/187152651305140403122334
ISSN:
18715265
e-ISSN:
18755852