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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Temporal cytokine gene expression patterns in subjects with trachoma identify distinct conjunctival responses associated with infection
Clinical and Experimental Immunology, Volume 142, No. 2, Year 2005
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Description
Ocular chlamydial disease is clinically diagnosed by the appearance of characteristic inflammatory changes and development of lymphoid follicles in the conjunctiva. Nucleic acid amplification tests and relatively non-invasive methods of sampling the conjunctival surface can be used to quantify the expression of chlamydial and host genes. Using quantitative real-time polymerase chain reaction to detect the presence of Chlamydia trachomatis (CT) 16S rRNA and human interleukin (IL)-1β, IL-10, IL-12p40, interferon (IFN)-γ and tumour necrosis factor (TNF)-α transcripts we examined the immune response at the conjunctival surface in a cohort of children living in a trachoma-endemic village in The Gambia. Elevated cytokine transcript levels were associated with the presence of CT 16S rRNA. Subclinical infection (CT infection without clinical signs of disease) elicited an immune response that is proinflammatory in nature, with elevations in the transcription of IL-1β, IFN-γ and IL-12p40. Clinically apparent infections were associated with the elevation of mRNA for the multi-functional cytokine TNF-α (fibrotic, type 1 inflammatory and regulatory) and the counter regulatory cytokine, IL-10, in addition to the other proinflammatory cytokines. A positive correlation between IFN-γ transcript levels and the amount of CT 16S rRNA expressed in conjunctiva was found. © 2005 British Society for Immunology.
Authors & Co-Authors
Faal, Nkoyo
Unknown Affiliation
Bailey, Robin L.
Unknown Affiliation
Sarr, Isatou
Unknown Affiliation
Joof, H. M.
Unknown Affiliation
Mabey, David C.W.
Unknown Affiliation
Holland, Martin J.
Unknown Affiliation
Statistics
Citations: 35
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1111/j.1365-2249.2005.02917.x
ISSN:
00099104
e-ISSN:
13652249
Research Areas
Cancer
Genetics And Genomics
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Gambia