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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Use of a mixture of lignocaine and bupivacaine vs lignocaine alone for male circumcision under local anaesthesia in Rakai, Uganda
BJU International, Volume 109, No. 7, Year 2012
Notification
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Description
Objective To assess self-reported pain control during and after surgery with a mixture of lignocaine and bupivacaine compared with lignocaine alone among male circumcision (MC) service recipients in Rakai, Uganda. Patients and Methods The two formulations of local anaesthesia for MC were used alternatively at weekly intervals in 360 patients; 179 received lignocaine alone and 181 received the lignocaine and bupivacaine mixture (LBmix). The proportions of men reporting pain during or after surgery, and the need for additional anaesthesia during surgery were determined for the LBmix vs lignocaine using Poisson adjusted rate ratios (RRs). Characteristics including age, weight, surgeon (medical officer vs clinical officer), surgical method and duration of surgery were compared between the arms using two-sample t-tests and chi-square tests. Results Patient and provider characteristics were comparable between the two anaesthetic groups. A higher proportion of patients reported pain during surgery in the lignocaine group (adjusted RR 11.6, 95% confidence interval [CI] 3.5-37.9, P < 0.001), required additional anaesthesia (adjusted RR 4.8, 95% CI 1.4-17.1, P= 0.015), and were more likely to report pain during the immediate postoperative period (adjusted RR 3.4, 95% CI 2.3-5.0, P < 0.001). These differences were particularly marked among patients with MC times longer than the median (adjusted RR 13.4, 95% CI 3.1-57.0, P < 0.001). Conclusions The LBmix significantly reduced pain associated with MC and the need for additional anaesthesia during MC. © 2011 The Authors. BJU International.
Authors & Co-Authors
Kigozi, Godfrey G.
Uganda, Kalisizo
Rakai Health Sciences Program
Musoke, Richard M.
Uganda, Kalisizo
Rakai Health Sciences Program
Anyokorit, Margaret
Uganda, Kalisizo
Rakai Health Sciences Program
Nkale, James Menya
Uganda, Kalisizo
Rakai Health Sciences Program
Kighoma, Nehemiah
Uganda, Kalisizo
Rakai Health Sciences Program
Ssebanenya, William
Uganda, Kalisizo
Rakai Health Sciences Program
Mwinike, Joshua
Uganda, Kalisizo
Rakai Health Sciences Program
Watya, Stephen
Uganda, Kampala
Makerere University
Nalugoda, Fred Kakaire
Uganda, Kalisizo
Rakai Health Sciences Program
Kagaayi, Joseph
Uganda, Kalisizo
Rakai Health Sciences Program
Nalwoga, Grace Kigozi
Uganda, Kalisizo
Rakai Health Sciences Program
Nakigozi, Gertrude F.
Uganda, Kalisizo
Rakai Health Sciences Program
Kiwanuka, Noah
Uganda, Kalisizo
Rakai Health Sciences Program
Uganda, Kampala
Makerere University
Makumbi, Fredrick Edward
Uganda, Kalisizo
Rakai Health Sciences Program
Uganda, Kampala
Makerere University
Lutalo, Tom
Uganda, Kalisizo
Rakai Health Sciences Program
Serwadda, David Musoke
Uganda, Kalisizo
Rakai Health Sciences Program
Uganda, Kampala
Makerere University
Wawer, Maria J.
Uganda, Kalisizo
Rakai Health Sciences Program
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Gray, Ronald H.
Uganda, Kalisizo
Rakai Health Sciences Program
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Statistics
Citations: 18
Authors: 18
Affiliations: 3
Identifiers
Doi:
10.1111/j.1464-410X.2011.10505.x
ISSN:
14644096
e-ISSN:
1464410X
Research Areas
Health System And Policy
Study Locations
Uganda
Participants Gender
Male