A Fourier transform infrared spectrophotometry method used for oseltamivir determination in pharmaceutical formulations
Gazi University Journal of Science, Volume 25, No. 3, Year 2012
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A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of oseltamivir phosphate (OP) in pharmaceutical formulations. Conventional KBr-spectra were compared for best determination of the active substance in pharmaceutical preparations. The Beer-Lambert law and two chemometric approaches, partial least squares (PLS) and principal component regression (PCR+) methods, were used in data processing.