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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Association between HLA class i and class ii alleles and the outcome of West Nile Virus infection: An exploratory study
PLoS ONE, Volume 6, No. 8, Article e22948, Year 2011
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Description
Background: West Nile virus (WNV) infection is asymptomatic in most individuals, with a minority developing symptoms ranging from WNV fever to serious neuroinvasive disease. This study investigated the impact of host HLA on the outcome of WNV disease. Methods: A cohort of 210 non-Hispanic mostly white WNV + subjects from Canada and the U.S. were typed for HLA-A, B, C, DP, DQ, and DR. The study subjects were divided into three WNV infection outcome groups: asymptomatic (AS), symptomatic (S), and neuroinvasive disease (ND). Allele frequency distribution was compared pair-wise between the AS, S, and ND groups using χ2 and Fisher's exact tests and P values were corrected for multiple comparisons (Pc). Allele frequencies were compared between the groups and the North American population (NA) used as a control group. Logistic regression analysis was used to evaluate the potential synergistic effect of age and HLA allele phenotype on disease outcome. Results: The alleles HLA-A*68, C*08 and DQB*05 were more frequently associated with severe outcomes (ND vs. AS, P A*68 = 0.013/Pc = 0.26, P C*08 = 0.0075/Pc = 0.064, and P DQB1*05 = 0.029/Pc = 0.68), However the apparent DQB1*05 association was driven by age. The alleles HLA-B*40 and C*03 were more frequently associated with asymptomatic outcome (AS vs. S, P B*40 = 0.021/Pc = 0.58 and AS vs. ND P C*03 = 0.039/Pc = 0.64) and their frequencies were lower within WNV + subjects with neuroinvasive disease than within the North American population (NA vs. S, P B*40 = 0.029 and NA vs. ND, P C*03 = 0.032). Conclusions: Host HLA may be associated with the outcome of WNV disease; HLA-A*68 and C*08 might function as "susceptible" alleles, whereas HLA-B*40 and C*03 might function as "protective" alleles. © 2011 Lanteri et al.
Authors & Co-Authors
Kaidarova, Zhanna
United States, San Francisco
Vitalant Research Institute
Peterson, Trevor A.
Canada, Ottawa
Public Health Agency of Canada
Custer, Brian S.
United States, San Francisco
Vitalant Research Institute
United States, Seattle
University of Washington
United States, San Francisco
University of California, San Francisco
Bielawny, Thomas
Canada, Ottawa
Public Health Agency of Canada
Plummer, Francis Allan
Canada, Ottawa
Public Health Agency of Canada
Canada, Winnipeg
University of Manitoba
Tobler, Leslie H.
United States, San Francisco
Vitalant Research Institute
Loeb, Mark B.
Canada, Hamilton
Mcmaster University
Busch, Michael P.
United States, San Francisco
Vitalant Research Institute
United States, San Francisco
University of California, San Francisco
Luo, Ma
Canada, Ottawa
Public Health Agency of Canada
Canada, Winnipeg
University of Manitoba
Norris, Philip J.
United States, San Francisco
Vitalant Research Institute
United States, San Francisco
University of California, San Francisco
Statistics
Citations: 31
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.1371/journal.pone.0022948
ISSN:
19326203
Research Areas
Genetics And Genomics
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Exploratory Study
Study Approach
Quantitative