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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Respiratory syncytial virus infections in hospitalized infants: Association between viral load, virus subgroup, and disease severity
Journal of Medical Virology, Volume 79, No. 12, Year 2007
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Description
The relationships between host factors, virus strain, viral load, and illness severity in respiratory syncytial virus (RSV)-induced bronchiolitis are poorly defined. These relationships were evaluated prospectively in 81 previously healthy infants hospitalized with RSV bronchiolitis. Disease severity was determined by the respiratory rate, the duration of hospitalization, and whether patients during their hospitalization required pediatric intensive care unit admission or mechanical ventilation. RSV typing into subgroup A and B was obtained by RT-PCR-hybridization assay. The nasopharyngeal RSV viral loads were measured by real-time quantitative RT-PCR. Disease severity correlated significantly with the presence of risk factor (estimated gestational age < 37 weeks and/or birth weight < 2,500 g) and with chronologic age ≤ 28 days at time of sample collection. The results revealed significant association between disease severity and nasopharyngeal RSV viral load. Analysis also showed that disease severity was not associated significantly with RSV subgroup. Thus, RSV disease severity is likely to be determined by an interplay between host and virus factors, including RSV load. © 2007 Wiley-Liss, Inc.
Authors & Co-Authors
Fodha, Imène
Tunisia, Sousse
Chu Sahloul
Vabret, Astrid
France, Caen
Chu de Caen Normandie
Ghédira, Leila
Tunisia, Monastir
Chu Fattouma-bourguiba
Séboui, Hassen
Tunisia, Sousse
Hopital Farhat Hached Sousse
Chouchane, Slaheddine
Tunisia, Monastir
Chu Fattouma-bourguiba
Dewar, John Barr
South Africa, Sovenga
University of Limpopo
Gueddiche, Néji M.
Tunisia, Monastir
Chu Fattouma-bourguiba
Trabelsi, Abdelhalim
Tunisia, Sousse
Chu Sahloul
Boujâafar, Noureddine
Tunisia, Sousse
Chu Sahloul
Freymuth, François L.
France, Caen
Chu de Caen Normandie
Statistics
Citations: 142
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1002/jmv.21026
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Genetics And Genomics
Study Approach
Quantitative