Publication Details

AFRICAN RESEARCH NEXUS

SHINING A SPOTLIGHT ON AFRICAN RESEARCH

immunology and microbiology

Respiratory syncytial virus infections in hospitalized infants: Association between viral load, virus subgroup, and disease severity

Journal of Medical Virology, Volume 79, No. 12, Year 2007

The relationships between host factors, virus strain, viral load, and illness severity in respiratory syncytial virus (RSV)-induced bronchiolitis are poorly defined. These relationships were evaluated prospectively in 81 previously healthy infants hospitalized with RSV bronchiolitis. Disease severity was determined by the respiratory rate, the duration of hospitalization, and whether patients during their hospitalization required pediatric intensive care unit admission or mechanical ventilation. RSV typing into subgroup A and B was obtained by RT-PCR-hybridization assay. The nasopharyngeal RSV viral loads were measured by real-time quantitative RT-PCR. Disease severity correlated significantly with the presence of risk factor (estimated gestational age < 37 weeks and/or birth weight < 2,500 g) and with chronologic age ≤ 28 days at time of sample collection. The results revealed significant association between disease severity and nasopharyngeal RSV viral load. Analysis also showed that disease severity was not associated significantly with RSV subgroup. Thus, RSV disease severity is likely to be determined by an interplay between host and virus factors, including RSV load. © 2007 Wiley-Liss, Inc.
Statistics
Citations: 142
Authors: 10
Affiliations: 5
Identifiers
Research Areas
Genetics And Genomics
Study Approach
Quantitative