Determination of candesartan cilexetil in tablet dosage forms and dissolution testing samples by first derivative uv spectrophotometric method

This article describes the development and validation of a first derivative UV quantitative analytical method for determination of candesartan cilexetil in tablet dosage forms. A signal at 270.1nm of the first derivative spectrum (ID270.1) was found adequate for quantification. The limit of quantification was 3.06 μg/ml. The linearity between ID270.1 nm and concentration of candesartan cilexetil in the range of 6.00-32.00 μg/ml presented a correlation coefficient of (r2)=0.9990. The mean recovery percentage was 100.97 and 99.23% for candesartan cilexetil standard solution and candesartan standard cilexetil solution with excipients, respectively. The intraday and interday accuracy of the assay was 98.60% and 99.10% respectively. The intraday and interday variability was below 2.0%. The proposed method is accurate, precise, sensitive, and selective and can be used in quality control laboratories for its intended purpose. © Taylor & Francis Group, LLC.