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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries
Clinical Cancer Research, Volume 11, No. 23, Year 2005
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Description
Purpose: The epidemiology of colorectal carcinoma is well known to differ among countries but the molecular characteristics are usually assumed to be similar. International differences in molecular pathology have not been studied extensively but have implications for the management of patients in different countries and of immigrant patients. Experimental Design: We evaluated the CpG island methylator phenotype pathway characterized by concordant methylation of gene promoters that often silences transcription of the genes, the microsatellite instability pathway, and K-ras and p53 gene status in 247 colorectal carcinomas from the three selected Middle Eastern countries of Egypt, Jordan, and Turkey. Results: Colorectal carcinoma from Egypt had the lowest frequencies of methylation. In multinomial logistic regression analysis, Jordanian colorectal carcinoma more frequently had methylation involving the p16 tumor suppressor gene (odds ratio, 3.5; 95% confidence interval, 1.2-10.6; P = 0.023) and MINT31 locus (odds ratio, 2.3; 95% confidence interval, 1.0-5.1; P = 0.041). The K-ras proto-oncogene was more frequently mutated in colorectal carcinoma from Turkey (odds ratio, 2.9; 95% confidence interval, 1.2-6.7; P = 0.016), but p53 overexpression was more common in both Jordanian and Turkish colorectal carcinoma than in Egyptian cases (odds ratio, 2.5; 95% confidence interval, 1.2-5.5; P = 0.019; and odds ratio, 3.6; 95% confidence interval, 1.8-7.1; P = 0.0003, respectively). The findings in Turkish colorectal carcinoma were most similar to those reported for Western cases. Conclusions: Colorectal carcinoma from Middle Eastern countries have differing gene methylation patterns and mutation frequencies that indicate dissimilar molecular pathogenesis, probably reflecting different environmental exposures. These molecular differences could affect prevention strategies, therapeutic efficacy, and transferability of clinical trial results. © 2005 American Association for Cancer Research.
Authors & Co-Authors
Chan, Annie On On
United States, Houston
The University of Texas Md Anderson Cancer Center
Hong Kong, Hong Kong
The University of Hong Kong
Soliman, Amr S.
United States, Houston
The University of Texas Md Anderson Cancer Center
United States, Ann Arbor
University of Michigan School of Public Health
Zhang, Qing
United States, Houston
The University of Texas Md Anderson Cancer Center
Rashid, Asif
United States, Houston
The University of Texas Md Anderson Cancer Center
Bedeir, Ahmed
United States, Houston
The University of Texas Md Anderson Cancer Center
Houlihan, Patrick Scott
United States, Houston
The University of Texas Md Anderson Cancer Center
Mokhtar, Nadia Mahmoud
Egypt, Giza
Cairo University
Al-Masri, Nidal
Jordan, Irbid
Jordan University of Science and Technology
Özbek, Uǧur
Turkey, Istanbul
Istanbul Üniversitesi
Yaghan, Rami Jalal
Jordan, Irbid
Jordan University of Science and Technology
Kandilci, Ayten
Turkey, Istanbul
Istanbul Üniversitesi
Omar, Sherif
Egypt, Giza
Cairo University
Kapran, Yersu
Turkey, Istanbul
Istanbul Üniversitesi
Dizdaroglu, Ferhunde
Turkey, Istanbul
Istanbul Üniversitesi
Bondy, Melissa L.
United States, Houston
The University of Texas Md Anderson Cancer Center
Amos, Christopher I.
United States, Houston
The University of Texas Md Anderson Cancer Center
Issa, Jean Pierre
United States, Houston
The University of Texas Md Anderson Cancer Center
Levin, Bernard
United States, Houston
The University of Texas Md Anderson Cancer Center
Hamilton, Stanley R.
United States, Houston
The University of Texas Md Anderson Cancer Center
Statistics
Citations: 19
Authors: 19
Affiliations: 6
Identifiers
Doi:
10.1158/1078-0432.CCR-05-1000
ISSN:
10780432
Research Areas
Cancer
Genetics And Genomics
Study Design
Case-Control Study
Study Approach
Quantitative
Study Locations
Egypt