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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Update on diagnostic and treatment of uncomplicated and complicated malaria in adults and selected vulnerable populations
Infectious Disorders - Drug Targets, Volume 13, No. 4, Year 2013
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Description
Although malaria remains one of the most important infectious causes of morbidity and mortality world-wide with 40% of the global population at risk, significant progress has been made toward elimination, notably with the development and use of rapid diagnostic tests, insecticide-treated bed nets, indoor residual spraying, and artemisinin-based combination therapies (ACTs). P. falciparum infection remains the most common cause of severe infection and death, but non-P. P. falciparum infections, including the recently emerged 5th plasmodium species, P. knowlesi, are increasingly recognized as causes of severe disease, especially in southeast Asia. Chemotherapy for severe infections has been revolutionized following results of the SEQUAMAT and AQUAMAT trials showing that parenteral artesunate (versus quinine) reduced severe malaria mortality by 34.7% and 22.5% in Asian adults and African children, respectively, making it the drug of choice for severe malaria. However, rising rates of artemisinin resistance, currently confined to the Greater Mekong sub-region, are threatening the long-term efficacy of artemisinins. HIV infection remains an important risk factor for death and severe disease due to malaria. The full amplitude of mutual interactions between these conditions is only beginning to be elucidated while the complex, multi-directional and pharmacokinetic interactions between antimalarial agents and HIV drugs continue to emerge. © 2013 Bentham Science Publishers.
Authors & Co-Authors
Botha, Philip
South Africa, Tygerberg
Tygerberg Hospital
Bottieau, Emmanuel
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Uthman, Olalekan A.
United Kingdom, Coventry
Warwick Medical School
Obike, Ude
South Africa, Tygerberg
Tygerberg Hospital
Nachega, J. B.
South Africa, Tygerberg
Tygerberg Hospital
United States, Pittsburgh
Graduate School of Public Health
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Statistics
Citations: 5
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.2174/1871526513666140103122630
ISSN:
18715265
e-ISSN:
18755852
Research Areas
Cancer
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study