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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Melanomas display increased cytoprotection to hypericin-mediated cytotoxicity through the induction of autophagy
Cell Biology International, Volume 33, No. 10, Year 2009
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Description
Photodynamic therapy (PDT) as a regime for melanoma is of limited success due to factors such as the efficacy of the photosensitizer used, penetration depth and the presence of pigment. We characterised a pigmented and an unpigmented melanoma cell line with respect to their phenotypes. Cell viability was assessed after exposure to hypericin, a UVA-activated photosensitizer. Exposure to 3 μM activated hypericin induced a cytoprotective (autophagic) response from both cell lines. However, the pigmented cells accumulated a large amount of glycogen in their cytoplasm. We hypothesise that the treatment induces an initial cytoprotective response through autophagy, but with increased stress results in a different mode of cell death in pigmented melanoma cells from unpigmented cells. These results indicate that hypericin-PDT could be an adjuvant therapy for melanoma. © 2009 International Federation for Cell Biology.
Authors & Co-Authors
Davids, Lester Merlin
South Africa, Cape Town
Faculty of Health Sciences
Kleemann, Britta
South Africa, Cape Town
Faculty of Health Sciences
Cooper, Susan
South Africa, Cape Town
Faculty of Health Sciences
Kidson, Susan Hillary
South Africa, Cape Town
Faculty of Health Sciences
Statistics
Citations: 50
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/j.cellbi.2009.06.026
ISSN:
10656995