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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Burden of typhoid and paratyphoid fever in a densely populated urban community, Dhaka, Bangladesh
International Journal of Infectious Diseases, Volume 14, No. SUPPL. 3, Year 2010
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Description
Background: We conducted blood culture surveillance to estimate the incidence of typhoid and paratyphoid fever among urban slum residents in Dhaka, Bangladesh. Methods: Between January 7, 2003 and January 6, 2004, participants were visited weekly to detect febrile illnesses. Blood cultures were obtained at the clinic from patients with fever (≥38 °C). Salmonella isolates were assayed for antimicrobial susceptibility. Results: Forty Salmonella Typhi and eight Salmonella Paratyphi A were isolated from 961 blood cultures. The incidence of typhoid fever was 2.0 episodes/1000 person-years, with a higher incidence in children aged < 5 years (10.5/1000 person-years) than in older persons (0.9/1000 person-years) (relative risk. = 12, 95% confidence interval (CI) 6.3-22.6). The incidence of paratyphoid fever was 0.4/1000 person-years without variation by age group. Sixteen S. Typhi isolates were multidrug-resistant (MDR). All S. Paratyphi isolates were pan-susceptible. The duration of fever among patients with an MDR S. Typhi infection was longer than among patients with non-MDR S. Typhi (16 ± 8 vs. 11 ± 4 days, p= 0.02) and S. Paratyphi (10 ± 2 days, p= 0.04) infections. Conclusions: Typhoid fever is more common than paratyphoid fever in the urban Bangladeshi slum; children < 5 years old have the highest incidence. Multidrug resistance is common in S. Typhi isolates and is associated with prolonged illness. Strategies for typhoid fever prevention in children aged < 5 years in Bangladesh, including immunization, are needed. © 2010 International Society for Infectious Diseases.
Authors & Co-Authors
Naheed, Aliya
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Ram, Pavani Kalluri
United States, Atlanta
Centers for Disease Control and Prevention
United States, Buffalo
University at Buffalo, the State University of new York
Brooks, W. Abdullah
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Hossain, Mohammad Anowar
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Parsons, Michele B.
United States, Atlanta
Centers for Disease Control and Prevention
Talukder, Kaisar Ali
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Mintz, Eric Daniel
United States, Atlanta
Centers for Disease Control and Prevention
Luby, Stephen P.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
United States, Atlanta
Centers for Disease Control and Prevention
Breiman, Robert F.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Statistics
Citations: 84
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1016/j.ijid.2009.11.023
ISSN:
12019712
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study