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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Antiangiogenic activity and pharmacogenomics of medicinal plants from traditional Korean medicine
Evidence-based Complementary and Alternative Medicine, Volume 2013, Article 131306, Year 2013
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Description
Aim. In the present study, we investigated the antiangiogenic properties of 59 plants used in traditional Korean medicine. Selected phytochemicals were investigated in more detail for their modes of action. Methods. A modified chicken-chorioallantoic-membrane (CAM) assay using quail eggs was applied to test for antiangiogenic effects of plant extracts. A molecular docking in silico approached the binding of plant constituents to the vascular endothelial growth factor receptors 1 and 2 (VEGFR1, VEGFR2). Microarray-based mRNA expression profiling was employed to correlate the 50% inhibition concentrations (IC 50) of a panel of 60 NCI cell lines to these phytochemicals. Results. Extracts from Acer mono leaves, Reynoutria sachalniensis fruits, Cinnamomum japonicum stems, Eurya japonica leaves, Adenophora racemosa whole plant, Caryopteris incana leaves-stems, and Schisandra chinensis stems inhibited angiogenesis more than 50% in quail eggs. Selected phytochemicals from Korean plants were analyzed in more detail using microarray-based mRNA expression profiles and molecular docking to VEGFR1 and VEGFR2. These results indicate multifactorial modes of action of these natural products. Conclusion. The antiangiogenic activity of plants used in traditional Korean medicine implicates their possible application for diseases where inhibition of blood vessel formation is desired, for example, cancer, macular degeneration, diabetic retinopathy and others. © 2013 Ean-Jeong Seo et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3736538/bin/131306.f1.pdf
Authors & Co-Authors
Seo, Ean Jeong
Germany, Mainz
Johannes Gutenberg-universität Mainz
Kuete, Victor
Germany, Mainz
Johannes Gutenberg-universität Mainz
Cameroon, Dschang
University of Dschang
Kadioglu, Onat
Germany, Mainz
Johannes Gutenberg-universität Mainz
Krusche, Benjamin
Germany, Mainz
Johannes Gutenberg-universität Mainz
Schröder, Sven
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Greten, Henry Johannes
Portugal, Porto
Universidade do Porto
Germany, Heidelberg
Heidelberg School of Chinese Medicine
Arend, Joachim
Germany, Mainz
Johannes Gutenberg-universität Mainz
Lee, Iksoo
South Korea, Gwangju
Chonnam National University
Efferth, Thomas H.
Germany, Mainz
Johannes Gutenberg-universität Mainz
Statistics
Citations: 31
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1155/2013/131306
ISSN:
1741427X
e-ISSN:
17414288
Research Areas
Cancer
Health System And Policy