Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
In vitro antioxidant and antihyperlipidemic activities of Toddalia asiatica (L) Lam. Leaves in Triton WR-1339 and high fat diet induced hyperlipidemic rats
Food and Chemical Toxicology, Volume 60, Year 2013
Notification
URL copied to clipboard!
Description
The present study was undertaken to evaluate the in vitro antioxidant and antihyperlipidemic activity of Toddalia asiatica (L) Lam. leaves in Triton WR-1339 and high fat diet-induced hyperlipidemic rats. In in vitro studies T. asiatica leaves ethyl acetate extract showed very good scavenging activity on 2,2-diphenyl-picrylhydrazyl (DPPH) (IC50 605.34±2.62μg/ml), hydroxyl (IC50 694.37±2.12μg/ml) and nitric oxide (IC50 897.83±1.48μg/ml) radicals, as well as high reducing power. In Triton WR-1339 induced hyperlipidemic rats, oral treatment with T. asiatica leaves ethyl acetate extract produced a significant (P≤0.005) decrease in the levels of serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), and significant increase in high-density lipoprotein cholesterol (HDL-C) in comparison with hexane and methanol extracts. In high fat diet-fed hyperlipidemic rats, the ethyl acetate extract (200 and 400mg/kg) significantly altered the plasma and liver lipids levels to near normal. © 2013 Elsevier Ltd.
Authors & Co-Authors
Irudayaraj, Santiagu Stephen
India, Chennai
Loyola College, Chennai
Sunil, Christudas
India, Chennai
Loyola College, Chennai
Duraipandiyan, V.
Saudi Arabia, Riyadh
College of Sciences
Ignacimuthu, Savarimuthu J.
India, Chennai
Loyola College, Chennai
Statistics
Citations: 40
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.fct.2013.07.035
ISSN:
02786915
e-ISSN:
18736351
Research Areas
Health System And Policy