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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Impact of maternal HAART on the prevention of mother-to-child transmission of HIV: Results of an 18-month follow-up study in Ouagadougou, Burkina Faso
AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, Volume 22, No. 7, Year 2010
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Description
Mother-to-child transmission remains the main cause of global pediatric HIV infections, especially in sub-Saharan Africa. Many interventions based on single-dose antiretroviral therapy have been implemented to reduce the mother-to-child transmission of HIV. In resource-limited settings, highly active antiretroviral therapy (HAART) has only been recommended for HIV-infected pregnant women requiring treatment for their own health. Here, we assessed the efficacy over 18 months of maternal HAART versus peripartum short-course antiretroviral therapy (SCART) regimens for the prevention of mother-to-child transmission (PMTCT) of HIV. We conducted a retrospective cohort study of patients from two medical centers in Ouagadougou, Burkina Faso. The PMTCT files and registers from 1 January 2003 to 31 December 2006 were obtained from routine data collected at these sites. The main assessment criterion was the rate of HIV-1 positivity in children born to HIV-positive mothers as measured with HIV-1 rapid tests at 18 months. A total of 586 pregnant HIV-1-infected women in PMTCT programs were selected. Among these women, 260 were undergoing HAART and 326 received single-dose nevirapine (91.3%) or single-dose zidovudine (8.7%) at delivery. HIV-1 serological tests were performed on 454 children at 18 months old. The rate of HIV-1 vertical transmission was 0% (0/195) in the HAART group and 4.6% (12/259) in the single-dose monotherapy group (P < 0.01). Eight infants in the HAART cohort and 30 in the SCART cohort were breastfed; three in the SCART group were HIV-positive. A total of 62 children died, 19 in the HAART group and 43 in the single-dose monotherapy group. Our study confirms that HAART for mothers effectively reduces the risk of infant HIV infection while preserving the breastfeeding option for mothers. © 2010 Taylor & Francis.
Authors & Co-Authors
Kouanda, Sèni
Burkina Faso, Ouagadougou
Institut de Recherche en Sciences de la Santé
Tougri, Halima
Burkina Faso, Ouagadougou
Institut de Recherche en Sciences de la Santé
Cissé, Mireille
United States, New York
Unicef
Simpore, J.
Unknown Affiliation
Pietra, Virginio
Unknown Affiliation
Doulougou, Boukaré
Burkina Faso, Ouagadougou
Institut de Recherche en Sciences de la Santé
Ouédraogo, Gautier Henri
Burkina Faso, Ouagadougou
Institut de Recherche en Sciences de la Santé
Ouédraogo, Charlemagne Marie Ragnag Néwendé
Burkina Faso, Ouagadougou
University of Ouagadougou
Soudré, Robert B.
Burkina Faso, Ouagadougou
University of Ouagadougou
Sondo, Blaise K.
Burkina Faso, Ouagadougou
Institut de Recherche en Sciences de la Santé
Statistics
Citations: 40
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1080/09540120903499204
ISSN:
09540121
e-ISSN:
13600451
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Burkina Faso
Participants Gender
Female