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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Comparison of the minimental state examination scale and the international hiv dementia scale in assessing cognitive function in nigerian HIV patients on antiretroviral therapy
AIDS Research and Treatment, Volume 2012, Article 581531, Year 2012
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Description
Introduction. HIV-associated neurocognitive disorder (HAND) remains common despite the availability of antiretroviral therapy. Routine screening will improve early detections. Objective. To compare the performance of the minimental state examination (MMSE) and international HIV dementia scale (IHDS) in assessing neurocognitive function in HIV/AIDS patients on antiretroviral therapy. Methods. A case-control study of 208 HIV-positive and 121 HIV-negative individuals. Baseline demographic data were documented and cognitive function assessed using the two instruments. CD4 cell counts were recorded. Results. Cases comprised 137 females and 71 males. Controls were 86 females and 35 males. Mean MMSE score of cases was 27.7 ± 1.8 compared to 27.8 ± 1.3 in controls (P = 0.54). Mean IHDS score in cases was 8.36 ± 3.1 compared to 10.7 ± 0.9 in controls (P < 0.001). Using the MMSE scale, 6 cases but no controls had HAND (P = 0.09). Using the IHDS, 113 (54.3%) had HAND compared with 10 (8.3%) controls (P < 0.0001). Using IHDS, 56.5% cases with CD4 count > 200 had HAND compared with 92.5% with CD4 count < 200 (P < 0.001). Conclusion. These findings indicate that the IHDS detects higher rates of HAND and may identify HIV/AIDS patients who require further cognitive assessment using more robust assessment batteries. © 2012 O. Olajumoke Oshinaike et al.
Authors & Co-Authors
Oshinaike, Olajumoke O.
Nigeria, Lagos
Lagos State University
Akinbami, Akinsegun Abduljaleel
Nigeria, Lagos
Lagos State University
Ojo, Oluwadamilola Omolara
Nigeria, Lagos
University of Lagos
Ojini, Francis Ibe
Nigeria, Lagos
University of Lagos
Okubadejo, Njideka U.
Nigeria, Lagos
University of Lagos
Danesi, Mustapha Abudu
Nigeria, Lagos
University of Lagos
Statistics
Citations: 41
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1155/2012/581531
e-ISSN:
20901259
Research Areas
Infectious Diseases
Mental Health
Study Design
Case-Control Study
Participants Gender
Female