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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Immunogenicity of an HPV-16 L2 DNA vaccine
Vaccine, Volume 27, No. 46, Year 2009
Notification
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Description
The ability to elicit cross-neutralizing antibodies makes human papillomavirus (HPV) L2 capsid protein a possible HPV vaccine. We examined and compared the humoral response of mice immunized with a HPV-16 L2 DNA vaccine or with HPV-16 L2 protein. The L2 DNA vaccine elicited a non-neutralizing antibody response unlike the L2 protein. L2 DNA vaccination suppressed the growth of L2-expressing C3 tumor cells, which is a T cell mediated effect, demonstrating that the lack of non-neutralizing antibody induction by L2 DNA was not caused by lack of T cell immunogenicity of the construct. © 2009 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Hitzeroth, I. I.
South Africa, Cape Town
Institute of Infectious Disease and Molecular Medicine
South Africa, Cape Town
University of Cape Town
Passmore, Jo Ann Shelley
South Africa, Cape Town
Institute of Infectious Disease and Molecular Medicine
Shephard, Enid G.
South Africa, Cape Town
Faculty of Health Sciences
Stewart, Deborah
South Africa, Cape Town
Institute of Infectious Disease and Molecular Medicine
Müller, Martin
Germany, Heidelberg
German Cancer Research Center
Williamson, Anna Lise
South Africa, Cape Town
Institute of Infectious Disease and Molecular Medicine
South Africa, Observatory
Groote Schuur Hospital
Rybicki, Edward P.
South Africa, Cape Town
Institute of Infectious Disease and Molecular Medicine
South Africa, Cape Town
University of Cape Town
Kast, W. Martin
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
United States, Honolulu
University of Hawaiʻi Cancer Center
Statistics
Citations: 24
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1016/j.vaccine.2009.06.015
ISSN:
0264410X
Research Areas
Cancer
Genetics And Genomics