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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Comparing serologic response against enteric pathogens with reported diarrhea to assess the impact of improved household drinking water quality
American Journal of Tropical Medicine and Hygiene, Volume 77, No. 1, Year 2007
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Description
We evaluated enteric infection serology as an alternative outcome measure to diarrhea prevalence in a randomized controlled trial of household-based drinking water treatment; 492 households were randomly assigned to 5 household-based water treatment interventions or control. Individuals were followed weekly over 52 weeks to measure diarrhea prevalence. Study subjects of age ≥ 6 months and < 24 months had blood drawn at entry and exit from the study or age cohort. Serologic assays for Cryptosporidium parvum, Giardia intestinalis, enterotoxigenic Escherichia coli (ETEC), and Norovirus were done. Of 343 subjects eligible for the study, the proportions of subjects experiencing serologic responses were 56% for Norovirus, 24% for C. parvum, 10% for ETEC, and 16% for G. intestinalis. Serologic response was associated with increased diarrhea prevalence only for G. intestinalis (P = 0.0134). Serologic response to the antigens tested for G. intestinalis but not for Norovirus, C. parvum, and ETEC may be a useful health-effect measure. Larger intervention studies that yield a more marked effect on diarrheal disease, use additional and improved serologic assays, and that collect serum samples at more frequent intervals are needed. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Crump, John A.
United States, Atlanta
Centers for Disease Control and Prevention
Mendoza, Carlos E.
United States, Atlanta
Centers for Disease Control and Prevention
Priest, Jeffrey W.
United States, Atlanta
National Center for Infectious Diseases
Glass, Roger I.M.
United States, Atlanta
Centers for Disease Control and Prevention
Monroe, Stephan S.
United States, Atlanta
Centers for Disease Control and Prevention
Bibb, William F.
United States, Atlanta
Centers for Disease Control and Prevention
Lopez, B. R.
United States, Atlanta
Centers for Disease Control and Prevention
Mintz, Eric Daniel
United States, Atlanta
Centers for Disease Control and Prevention
Luby, Stephen P.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 33
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.4269/ajtmh.2007.77.136
ISSN:
00029637
Research Areas
Environmental
Health System And Policy
Infectious Diseases
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Study Approach
Quantitative