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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
HIV-1 subtype C superinfected individuals mount low autologous neutralizing antibody responses prior to intrasubtype superinfection
Retrovirology, Volume 9, Article 76, Year 2012
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Description
Background: The potential role of antibodies in protection against intra-subtype HIV-1 superinfection remains to be understood. We compared the early neutralizing antibody (NAb) responses in three individuals, who were superinfected within one year of primary infection, to ten matched non-superinfected controls from a Zambian cohort of subtype C transmission cases. Sequence analysis of single genome amplified full-length envs from a previous study showed limited diversification in the individuals who became superinfected with the same HIV-1 subtype within year one post-seroconversion. We hypothesized that this reflected a blunted NAb response, which may have made these individuals more susceptible to superinfection.Results: Neutralization assays showed that autologous plasma NAb responses to the earliest, and in some cases transmitted/founder, virus were delayed and had low to undetectable titers in all three superinfected individuals prior to superinfection. In contrast, NAbs with a median IC50 titer of 1896 were detected as early as three months post-seroconversion in non-superinfected controls. Early plasma NAbs in all subjects showed limited but variable levels of heterologous neutralization breadth. Superinfected individuals also exhibited a trend toward lower levels of gp120- and V1V2-specific IgG binding antibodies but higher gp120-specific plasma IgA binding antibodies.Conclusions: These data suggest that the lack of development of IgG antibodies, as reflected in autologous NAbs as well as gp120 and V1V2 binding antibodies to the primary infection virus, combined with potentially competing, non-protective IgA antibodies, may increase susceptibility to superinfection in the context of settings where a single HIV-1 subtype predominates. © 2012 Basu et al.; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3477039/bin/1742-4690-9-76-S1.pdf
Authors & Co-Authors
Basu, Debby
United States, Atlanta
Emory University
Kraft, Colleen S.
United States, Atlanta
Emory University
Murphy, Megan K.
United States, Atlanta
Emory University
Campbell, Patricia J.
United States, Atlanta
Emory University
Yu, Tianwei
United States, Atlanta
Rollins School of Public Health
Hraber, Peter T.
United States, Los Alamos
Los Alamos National Laboratory
Irene, Carmela
United States, Newark
Public Health Research Institute
Pinter, Abraham
United States, Newark
Public Health Research Institute
Chomba, Elwyn Nachanya
Zambia, Lusaka
Zambia-emory Hiv Research Project
Mulenga, Joseph
Zambia, Lusaka
Zambia-emory Hiv Research Project
Kilembe, William
Zambia, Lusaka
Zambia-emory Hiv Research Project
Allen, Susan A.
United States, Atlanta
Emory University
United States, Atlanta
Rollins School of Public Health
Zambia, Lusaka
Zambia-emory Hiv Research Project
Rwanda, Kigali
Projet San Francisco
Derdeyn, Cynthia A.
United States, Atlanta
Emory University
Hunter, Eric
United States, Atlanta
Emory University
Statistics
Citations: 14
Authors: 14
Affiliations: 6
Identifiers
Doi:
10.1186/1742-4690-9-76
Research Areas
Infectious Diseases
Study Design
Cohort Study