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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Carbon monoxide protects the kidney through the central circadian clock and CD39
Proceedings of the National Academy of Sciences of the United States of America, Volume 115, No. 10, Year 2018
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Description
Ischemia reperfusion injury (IRI) is the predominant tissue insult associated with organ transplantation. Treatment with carbon monoxide (CO) modulates the innate immune response associated with IRI and accelerates tissue recovery. The mechanism has been primarily descriptive and ascribed to the ability of CO to influence inflammation, cell death, and repair. In a model of bilateral kidney IRI in mice, we elucidate an intricate relationship between CO and purinergic signaling involving increased CD39 ectonucleotidase expression, decreased expression of Adora1, with concomitant increased expression of Adora2a/2b. This response is linked to a >20-fold increase in expression of the circadian rhythm protein Period 2 (Per2) and a fivefold increase in serum erythropoietin (EPO), both of which contribute to abrogation of kidney IRI. CO is ineffective against IRI in Cd39−/− and Per2−/− mice or in the presence of a neutralizing antibody to EPO. Collectively, these data elucidate a cellular signaling mechanism whereby CO modulates purinergic responses and circadian rhythm to protect against injury. Moreover, these effects involve CD39- and adenosinergic-dependent stabilization of Per2. As CO also increases serum EPO levels in human volunteers, these findings continue to support therapeutic use of CO to treat IRI in association with organ transplantation, stroke, and myocardial infarction. © 2018 National Academy of Sciences. All Rights Reserved.
Authors & Co-Authors
Csizmadia, Eva
United States, Boston
Beth Israel Deaconess Medical Center
Gomperts, Edward D.
Unknown Affiliation
Hauser, Carl Jeffrey
United States, Boston
Beth Israel Deaconess Medical Center
Ji, Xingyue
United States, Atlanta
Georgia State University
Wang, Binghe
United States, Atlanta
Georgia State University
Câmara, Niels Olsen Saraiva
Brazil, Sao Paulo
Universidade de São Paulo
Robson, Simon Christopher
United States, Boston
Beth Israel Deaconess Medical Center
Statistics
Citations: 58
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1073/pnas.1716747115
ISSN:
00278424
Research Areas
Environmental
Noncommunicable Diseases
Violence And Injury
Study Design
Cross Sectional Study