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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Hormonal contraception and area of cervical ectopy: A longitudinal assessment
Contraception, Volume 84, No. 5, Year 2011
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Description
Background: The effect of combined oral contraceptives (COCs) and depot-medroxyprogesterone acetate (DMPA) on the area of cervical ectopy is not well understood. Study Design: From 1996 to 1999, we recruited women not using hormonal contraception from two family planning centers in Baltimore, MD. Upon study entry and 3, 6 and 12 months after the initial visit, participants were interviewed and received visual cervical examinations with photography. Ectopy was measured from digitized photographs and was analyzed both continuously and categorically (small [≤0.48 cm 2] vs. large [>0.48 cm 2]). Results: Of 1003 enrolled women, 802 returned for at least one follow-up visit. At 12 months, the numbers of women using COCs, DMPA or no hormonal method at least 50% of the time since the prior visit were 230, 76 and 229, respectively. After multivariable adjustment, COC use (vs. no hormonal use) was associated with large area of ectopy (odds ratio [OR]: 1.8, 95% confidence interval [CI]: 1.0-3.3). No significant relationship was observed between DMPA and large area of ectopy (OR: 0.5, 95% CI: 0.2-1.3). The incidence of large area of ectopy by contraceptive exposure (COC, DMPA or no hormonal method) was 17.4 (CI: 11.8-24.6), 10.9 (CI: 4.4-22.4) and 4.6 (CI: 2.2-8.4) per 100 woman-years, respectively. Conclusions: Use of COCs, but not DMPA, was associated with large area of cervical ectopy. Area of ectopy at baseline was the strongest predictor of area of ectopy at follow-up. © 2011 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Bright, Patricia
Uganda, Kampala
Makerere University
Turner, Abigail Norris
United States, Columbus
The Ohio State University
Morrison, Charles S.
United States, Durham
Fhi 360
Wong, Emelita L.
United States, Morrisville
Ppdi, Inc.
Kwok, Cynthia
United States, Durham
Fhi 360
Yacobson, Irina
United States, Durham
Fhi 360
Royce, Rachel A.
United States, Research Triangle Park
Rti International
Tucker, Heidi Toms
United States, New York
Pfizer Inc.
Blumenthal, Paul D.
United States, Baltimore
Planned Parenthood of Maryland
United States, Palo Alto
Stanford University
Statistics
Citations: 29
Authors: 9
Affiliations: 8
Identifiers
Doi:
10.1016/j.contraception.2011.02.002
ISSN:
00107824
e-ISSN:
18790518
Research Areas
Health System And Policy
Sexual And Reproductive Health
Study Design
Cohort Study
Case-Control Study
Participants Gender
Female