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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Alpha-thalassemia in Papua New Guinea
Human Genetics, Volume 74, No. 4, Year 1986
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Description
A study of the distribution of α-thalassemia in Papua New Guinea (PNG) was carried out by DNA analysis. A total of 664 DNA samples were screened for α-thalassemia 2 and α-thalassemia 1 caused respectively by either deletion of one or both of the duplicated α-globin genes. α-Thalassemia 2 was detected in high frequencies in coastal and lowland regions where malaria has been holo- to hyperendemic but in low frequencies in non-malarious highland regions. The highest frequency was observed in the north coast of PNG. The distribution of α-thalassemia 2 seems to be in accordance with other conditions such as ovalocytosis and G6PD deficiency which are also prevalent in this population, suggesting that they may interact in protection against malaria. However, it appears to be negatively correlated with β-thalassemia and α-thalassemia 1, the latter being extremely rare in this population. Analysis of the types and subtypes of the single α-globin gene deletion revealed a predominance of the -α4.2 type in general, except in some regions in the south where the -α3.7 type is prevalent. The -α3.7 I subtype is the common form of the -α3.7 deletion in the PNG mainland. The -α3.7 III subtype, previously reported to be unique in Melanesians and Polynesians, was detected in an offshore island of PNG. However, this subtype is very rare in Melanesians from the PNG mainland. © 1986 Springer-Verlag.
Authors & Co-Authors
Summers, Kim M.
Australia, Canberra
The Australian National University
Nurse, George T.
Unknown Affiliation
Statistics
Citations: 31
Authors: 2
Affiliations: 3
Identifiers
Doi:
10.1007/BF00280500
ISSN:
14321203
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Guinea