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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: Effectiveness of early intervention with budesonide in mild persistent asthma
Journal of Allergy and Clinical Immunology, Volume 121, No. 5, Year 2008
Notification
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Description
Background: The Inhaled Steroid Treatment as Regular Therapy in Early Asthma (START) study enrolled 7241 patients aged 5 to 66 years with recent-onset, mild persistent asthma to assess early intervention with the inhaled corticosteroid budesonide on long-term asthma control. Objective: The open-label phase of the START study was included to determine the effect on lung function and asthma control of adding budesonide to the reference group patients who had not initially received inhaled corticosteroids. Methods: Patients were randomized to double-blind treatment with budesonide, 200 mg (those aged <11 years) or 400 mg once daily, or placebo plus the usual asthma therapy for 3 years, after which all patients received 2 years of open-label treatment with budesonide once daily. Results: During the full 5-year study period, postbronchodilator FEV1 percent predicted decreased, irrespective of randomized treatment during the double-blind phase, by an average of 2.22% (SE, 0.15%). However, patients with inhaled budesonide in the double-blind phase had a significantly lower risk (odds ratio, 0.61; P <.001) of a severe asthma-related event during the full 5-year study period than those in the reference group. Moreover, patients in the reference group used more additional asthma medications during both the open-label and double-blind phases. Conclusions: In mild persistent asthma early intervention with inhaled budesonide was associated with improved asthma control and less additional asthma medication use. © 2008 American Academy of Allergy, Asthma & Immunology.
Authors & Co-Authors
Busse, William Walter
United States, Madison
University of Wisconsin School of Medicine and Public Health
Pedersen, Soøren Erik
Denmark, Kolding
Sygehus Lillebælt - Kolding
Pauwels, Romain A.R.
Belgium, Ghent
Universitair Ziekenhuis Gent
Tan, Wan Cheng
Singapore, Singapore City
National University of Singapore
Canada, Vancouver
St. Paul's Hospital, Vancouver
Chen, Yuzhi
China, Beijing
Capital Institute of Pediatrics
O'Byrne, Paul M.
Canada, Hamilton
Mcmaster University
Silverman, Michael A.
United Kingdom, Leicester
Leicester
Riedler, Josef
Unknown Affiliation
Van Bever, Hugo P.S.
Unknown Affiliation
Vincken, Walter G.
Unknown Affiliation
Joos, Guy F.P.
Unknown Affiliation
Pohunek, Petr
Unknown Affiliation
Panzner, Petr
Unknown Affiliation
Petrů, Vít
Unknown Affiliation
Valovirta, Erkka Juhani
Unknown Affiliation
Godard, Phillippe P.
Unknown Affiliation
Albertini, Marc
Unknown Affiliation
Le Roux, Pascal
Unknown Affiliation
von Berg, Andrea
Unknown Affiliation
Weber, Hans Henning
Unknown Affiliation
Gönczi, Ferenc
Unknown Affiliation
Bjåmer, Ditlef
Unknown Affiliation
Langhammer, Arnulf
Unknown Affiliation
Öymar, Knut Asbjørn Alexander
Unknown Affiliation
Szczeklik, Andrzej J.
Unknown Affiliation
Chyrek-Borowska, Sabina
Unknown Affiliation
Latoś, Tadeusz
Unknown Affiliation
Emeryk, Andrzej
Unknown Affiliation
Boznánski, Andrzej
Unknown Affiliation
Małolepszy, Józef
Unknown Affiliation
Siafakas, Nikolaos M.
Unknown Affiliation
Priftis, Kostas
Unknown Affiliation
Tal, Asher
Unknown Affiliation
Katz, Yitzhak
Unknown Affiliation
Rottem, Menachem
Unknown Affiliation
Rossi, Andrea
Unknown Affiliation
Boner, Attillio Loris
Unknown Affiliation
Fabbri, Leonardo M.
Unknown Affiliation
Montefort, Stephen R.
Unknown Affiliation
Nunes, Carlos Pereira
Unknown Affiliation
Bernstein, David Isaac
Unknown Affiliation
Casale, T. Bruce
Unknown Affiliation
Chervinsky, Paul S.
Unknown Affiliation
Welch, Michael J.
Unknown Affiliation
Lemanske, Robert F.
Unknown Affiliation
Lockey, Richard Funk
Unknown Affiliation
Stoloff, Stuart W.
Unknown Affiliation
Szefler, Stanley J.
Unknown Affiliation
Vandewalker, Mark L.
Unknown Affiliation
Weinstein, Steven F.
Unknown Affiliation
Teper, Alejandro Manuel
Unknown Affiliation
Zhou, Xin
Unknown Affiliation
Zhong, Nanshan
Unknown Affiliation
Kim, You-young
Unknown Affiliation
Quah, Ban Seng
Unknown Affiliation
de Bruyne, Jessie Anne
Unknown Affiliation
de Guia, Teresita S.
Unknown Affiliation
Ossip, Mervyn S.
Unknown Affiliation
Mercer, Madeleine J.
Unknown Affiliation
Cassim, Khalil M.
Unknown Affiliation
Bateman, Eric D.
Unknown Affiliation
Morison, Adrian
Unknown Affiliation
Nel, Haylene
Unknown Affiliation
Vermeulen, Jan H.
Unknown Affiliation
Weinberg, Eugene G.
Unknown Affiliation
Weber, Heinrich C.
Unknown Affiliation
Kuo, Hanping
Unknown Affiliation
Trakultivakorn, Muthita
Unknown Affiliation
Teeratakulpisarn, Jamaree
Unknown Affiliation
Boonsawat, Watchara
Unknown Affiliation
Statistics
Citations: 129
Authors: 70
Affiliations: 9
Identifiers
Doi:
10.1016/j.jaci.2008.02.029
ISSN:
00916749
Research Areas
Disability
Study Design
Randomised Control Trial
Cohort Study
Case-Control Study