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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
An investigation of transmission ratio distortion in the central region of the human MHC
Genes and Immunity, Volume 7, No. 1, Year 2006
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Description
Transmission ratio distortion (TRD) describes a significant departure from expected Mendelian inheritance ratios that is fundamental to both the biology of reproduction and statistical genetics. The relatively high fetal wastage in humans, with consequent selection of alleles in utero, makes it likely that TRD is prevalent in the human genome. The central region of the human major histocompatibility complex (MHC) is a strong TRD candidate, as it houses a number of immune and regulatory genes that may be important in pregnancy outcome. We used a nonhaplotype-based method to select 13 tagging SNPs from three central MHC candidate regions, and analysed their transmission in 380 newborns and their parents (1138 individuals). A TRD of 54:46 was noted in favour of the common allele of a promoter SNP in the CLIC1 gene (P = 0.025), with a similar distortion using haplotypes across the same gene region (P = 0.016). We also found evidence that markers in the CLIC1 gene region may have been subject to recent selection (P < 0.001). The study illustrates the potential benefits of screening for TRD and highlights the difficulties encountered therein. © 2006 Nature Publishing Group All rights reserved.
Authors & Co-Authors
Hanchard, Neil A.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Oxford
University of Oxford
Jamaica, Kingston
The University of the West Indies
Rockett, Kirk A.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Oxford
University of Oxford
Udalova, Irina A.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Wilson, Jonathan N.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Oxford
University of Oxford
Keating, Brendan J.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Koch, Oliver
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Nijnik, Anastasia
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Diakité, Mahamadou L.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Herbert, Mark A.
United Kingdom, Oxford
University of Oxford
Kwiatkowski, Dominic P.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 13
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1038/sj.gene.6364277
ISSN:
14765470
Research Areas
Genetics And Genomics
Maternal And Child Health
Sexual And Reproductive Health