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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Antibacterial activity of some natural products against bacteria expressing a multidrug-resistant phenotype
International Journal of Antimicrobial Agents, Volume 37, No. 2, Year 2011
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Description
The present study assessed the antimicrobial activities of various natural products belonging to the terpenoids, alkaloids and phenolics against a collection of Gram-negative multidrug-resistant (MDR) bacteria. The results demonstrated that most of the compounds were extruded by bacterial efflux pumps. In the presence of the efflux pump inhibitor phenylalanine arginine β-naphthylamide (PAβN), the activities of laurentixanthone B (xanthone), plumbagin (naphthoquinone), 4-hydroxylonchocarpin (flavonoid) and MAB3 (coumarin) increased significantly against all studied MDR bacteria. Laurentixanthone B, 4-hydroxylonchocarpin and MAB3 contained the same pharmacophoric moiety as plumbagin. This study indicates that the AcrAB-TolC (Enterobacteriaceae) and MexAB-OprM (Pseudomonas aeruginosa) efflux pumps are involved in resistance of Gram-negative bacteria to most of the natural products. © 2010 Elsevier B.V. and the International Society of Chemotherapy.
Authors & Co-Authors
Kuete, Victor
Cameroon, Dschang
University of Dschang
France, Marseille
Transporteurs Membranaires, Chimiorésistance et Drug-design
Alibert-Franco, Sandrine
France, Marseille
Transporteurs Membranaires, Chimiorésistance et Drug-design
Eyong, Kenneth Oben
Cameroon, Yaounde
Université de Yaoundé I
Ngameni, Bathélémy
Cameroon, Yaounde
Université de Yaoundé I
Folefoc, Gabriel Ngosong
Cameroon, Yaounde
Université de Yaoundé I
Nguemeving, Jean Robert
Cameroon, Yaounde
Université de Yaoundé I
Tangmouo, Jean Gustave
Cameroon, Yaounde
Université de Yaoundé I
Fotso, Ghislain Wabo
Cameroon, Yaounde
Université de Yaoundé I
Komguem, Justin
Cameroon, Yaounde
Université de Yaoundé I
Ouahouo, Blandine Marlyse Wache
Cameroon, Yaounde
Université de Yaoundé I
Bolla, Jean Michel
France, Marseille
Transporteurs Membranaires, Chimiorésistance et Drug-design
Chevalier, Jacqueline
France, Marseille
Transporteurs Membranaires, Chimiorésistance et Drug-design
Ngadjui, Bonaventure Tchaleu
Cameroon, Yaounde
Université de Yaoundé I
Nkengfack, Augustin Ephrem
Cameroon, Yaounde
Université de Yaoundé I
Pags, J. M.
France, Marseille
Transporteurs Membranaires, Chimiorésistance et Drug-design
Statistics
Citations: 125
Authors: 15
Affiliations: 3
Identifiers
Doi:
10.1016/j.ijantimicag.2010.10.020
ISSN:
09248579
Research Areas
Cancer