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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Field evaluation of Abbott Real Time HIV-1 Qualitative test for early infant diagnosis using dried blood spots samples in comparison to Roche COBAS Ampliprep/COBAS TaqMan HIV-1 Qual Test in Kenya
Journal of Virological Methods, Volume 204, Year 2014
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Description
Timely diagnosis and treatment of infants infected with HIV are critical for reducing infant mortality. High-throughput automated diagnostic tests like Roche COBAS AmpliPrep/COBAS TaqMan HIV-1 Qual Test (Roche CAPCTM Qual) and the Abbott Real Time HIV-1 Qualitative (Abbott Qualitative) can be used to rapidly expand early infant diagnosis testing services. In this study, the performance characteristics of the Abbott Qualitative were evaluated using two hundred dried blood spots (DBS) samples (100 HIV-1 positive and 100 HIV-1 negative) collected from infants attending the antenatal facilities in Kisumu, Kenya. The Abbott Qualitative results were compared to the diagnostic testing completed using the Roche CAPCTM Qual in Kenya. The sensitivity and specificity of the Abbott Qualitative were 99.0% (95% CI: 95.0-100.0) and 100.0% (95% CI: 96.0-100.0), respectively, and the overall reproducibility was 98.0% (95% CI: 86.0-100.0). The limits of detection for the Abbott Qualitative and Roche CAPCTM Qual were 56.5 and 6.9. copies/mL at 95% CIs (p= 0.005), respectively. The study findings demonstrate that the Abbott Qualitative test is a practical option for timely diagnosis of HIV in infants. © 2014.
Authors & Co-Authors
Chang, Joy Chih Wei
United States, Atlanta
Centers for Disease Control and Prevention
Omuomo, Kenneth
Kenya, Nairobi
Kenya Medical Research Institute
Anyango, Emily
Kenya, Nairobi
Kenya Medical Research Institute
King’wara, Leonard
Kenya, Nairobi
Kenya Medical Research Institute
Basiye, Frank L.
United States, Atlanta
Centers for Disease Control and Prevention
Morwabe, Alex
Kenya, Nairobi
Kenya Medical Research Institute
Shanmugam, Vedapuri
United States, Atlanta
Centers for Disease Control and Prevention
Nguyen, Shon
United States, Atlanta
Centers for Disease Control and Prevention
Sabatier, Jennifer F.
United States, Atlanta
Centers for Disease Control and Prevention
Zeh, Clement E.
Kenya, Nairobi
Kenya Medical Research Institute
Ellenberger, Dennis L.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 11
Authors: 11
Affiliations: 2
Identifiers
Doi:
10.1016/j.jviromet.2014.03.010
ISSN:
01660934
e-ISSN:
18790984
Research Areas
Infectious Diseases
Maternal And Child Health
Study Approach
Qualitative
Study Locations
Kenya