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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The burden of influenza and rsv among inpatients and outpatients in rural western Kenya, 2009-2012
PLoS ONE, Volume 9, No. 8, Article e105543, Year 2014
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Description
Background: In Kenya, detailed data on the age-specific burden of influenza and RSV are essential to inform use of limited vaccination and treatment resources. Methods: We analyzed surveillance data from August 2009 to July 2012 for hospitalized severe acute respiratory illness (SARI) and outpatient influenza-like illness (ILI) at two health facilities in western Kenya to estimate the burden of influenza and respiratory syncytial virus (RSV). Incidence rates were estimated by dividing the number of cases with laboratory-confirmed virus infections by the mid-year population. Rates were adjusted for healthcare-seeking behavior, and to account for patients who met the SARI/ILI case definitions but were not tested. Results: The average annual incidence of influenza-associated SARI hospitalization per 1,000 persons was 2.7 (95% CI 1.8-3.9) among children <5 years and 0.3 (95% CI 0.2-0.4) among persons ≥5 years; for RSV-associated SARI hospitalization, it was 5.2 (95% CI 4.0-6.8) among children ,5 years and 0.1 (95% CI 0.0-0.2) among persons ≥5 years. The incidence of influenza-associated medically-attended ILI per 1,000 was 24.0 (95% CI 16.6-34.7) among children <5 years and 3.8 (95% CI 2.6-5.7) among persons ≥5 years. The incidence of RSV-associated medically-attended ILI was 24.6 (95% CI 17.0-35.4) among children <5 years and 0.8 (95% CI 0.3-1.9) among persons ≥5 years. Conclusions: Influenza and RSV both exact an important burden in children. This highlights the possible value of influenza vaccines, and future RSV vaccines, for Kenyan children. © 2014 Emukule et al.
Authors & Co-Authors
Emukule, Gideon O.
United States, Atlanta
Centers for Disease Control and Prevention
Khagayi, Sammy
Kenya, Nairobi
Kenya Medical Research Institute
McMorrow, Meredith Lynn
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Ochola, Rachel
Kenya, Nairobi
Kenya Medical Research Institute
Otieno, Nancy A.
Kenya, Nairobi
Kenya Medical Research Institute
Widdowson, Marc Alain
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Ochieng, Melvin
Kenya, Nairobi
Kenya Medical Research Institute
Feikin, Daniel R.
United States, Atlanta
Centers for Disease Control and Prevention
Katz, Mark A.
United States, Atlanta
Centers for Disease Control and Prevention
Mott, Joshua Adam
United States, Atlanta
Centers for Disease Control and Prevention
United States, Atlanta
National Center for Immunization and Respiratory Diseases
Statistics
Citations: 78
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pone.0105543
e-ISSN:
19326203
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Kenya