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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
materials science
Stable conjugates of peptides with gold nanorods for biomedical applications with reduced effects on cell viability
ACS Applied Materials and Interfaces, Volume 5, No. 10, Year 2013
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Description
Gold nanorods used in therapy and diagnosis must be nontoxic and stable in biological media and should be specific for the target. The complete combination of these three factors has hindered the use of gold nanorods as carriers in biological and biomedical applications. In this study, we produced a conjugate of gold nanorods with the peptide CLPFFD that recognizes toxic β-amyloid aggregates present in Alzheimer's disease, demonstrates colloidal stability, maintains plasmonic properties, and shows no effects on cell viability in the SH-SY5Y cell line. Furthermore, the irradiation of β-amyloid in the presence of the conjugate with near-infrared region irradiation energy reduces the amyloidogenic process reducing also its cytotoxicity. The nanorods were synthesized following the seed-mediated method in cetyltrimethylammonium bromide (CTAB) and were conjugated with the N-terminal cysteine peptide, CLPFFD. The conjugate was exhaustively characterized using different techniques (Absorption spectroscopy, X-ray photoelectron spectroscopy, electron energy loss spectroscopy, and zeta potential). The effects on cell viability and cell penetration by transmission electron microscopy of the conjugate were evaluated. The chemisorption of the peptide on the surface of gold nanorods increases their stability and reduces their effects on cell viability. © 2013 American Chemical Society.
Authors & Co-Authors
Adura, Carolina
Chile, Santiago
Universidad de Santiago de Chile
Chile, Santiago
Universidad de Chile
Guerrero, Simon
Chile, Santiago
Universidad de Chile
Salas-Huenuleo, Edison
Chile, Santiago
Universidad de Santiago de Chile
Medel, Luis
Chile, Santiago
Universidad de Chile
Riveros, Ana L.
Chile, Santiago
Universidad de Chile
Mena, Juan F.
Chile, Santiago
Universidad de Chile
Arbiol, Jordi
Spain, Barcelona
Csic - Instituto de Ciencia de Materiales de Barcelona Icmab
Spain, Barcelona
Institució Catalana de Recerca I Estudis Avançats
Alberício, Fernando
Spain, Barcelona
Irb Barcelona - Institute for Research in Biomedicine
Spain, Barcelona
Universitat de Barcelona
South Africa, Durban
University of Kwazulu-natal
Giralt, Ernest
Spain, Barcelona
Irb Barcelona - Institute for Research in Biomedicine
Spain, Barcelona
Universitat de Barcelona
Kogan, Marcelo Javier
Chile, Santiago
Universidad de Chile
Statistics
Citations: 60
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.1021/am3028537
ISSN:
19448244
e-ISSN:
19448252
Research Areas
Environmental