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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Anaplasma phagocytophilum-Borrelia burgdorferi coinfection enhances chemokine, cytokine, and matrix metalloprotease expression by human brain microvascular endothelial cells
Clinical and Vaccine Immunology, Volume 14, No. 11, Year 2007
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Description
Borrelia burgdorferi and Anaplasma phagocytophilum coinfect and are transmitted by Ixodes species ticks. Clinical indicators suggest that A. phagocytophilum coinfection contributes to the severity, dissemination, and, possibly, sequelae of Lyme disease. Previous in vitro studies showed that spirochete penetration through human brain microvascular endothelial cells of the blood-brain barrier is facilitated by endothelial cell-derived matrix metalloproteases (MMPs). A. phagocytophilum-inkcted neutrophils continuously release MMPs and other vasoactive biomediators. We examined B. burgdorferi infection of brain microvascular barriers during A. phagocytophilum coinfection and showed that coinfection enhanced reductions in transendothelial electrical resistance and enhanced or synergistically increased production of MMPs (MMP-1, -3, -7, -8, and -9), cytokines (interleukin 6 [IL-6], IL-10, and tumor necrosis factor alpha), and chemokines (IL-8 and macrophage inflammatory protein 1α) known to affect vascular permeability and inflammatory responses. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Grab, Dennis J.
United States, Baltimore
Johns Hopkins University
Nyarko, Elvis
United States, Baltimore
Johns Hopkins University
Ghana, Accra
University of Ghana
Barat, Nicole C.
United States, Baltimore
Johns Hopkins University
Nikolskaia, Olga V.
United States, Baltimore
Johns Hopkins University
Dumler, John Stephen
United States, Baltimore
Johns Hopkins University
Statistics
Citations: 59
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1128/CVI.00308-07
ISSN:
15566811
e-ISSN:
1556679X
Research Areas
Cancer