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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Phylogeography and epidemic history of hepatitis C virus genotype 4 in Africa
Virology, Volume 464-465, No. 1, Year 2014
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Description
HCV genotype 4 is prevalent in many African countries, yet little is known about the genotype's epidemic history on the continent. We present a comprehensive study of the molecular epidemiology of genotype 4. To address the deficit of data from the Democratic Republic of the Congo (DRC) we PCR amplified 60 new HCV isolates from the DRC, resulting in 33 core- and 48 NS5B-region sequences. Our data, together with genotype 4 database sequences, were analysed using Bayesian phylogenetic approaches. We find three well-supported intra-genotypic lineages and estimate that the genotype 4 common ancestor existed around 1733 (1650-1805). We show that genotype 4 originated in central Africa and that multiple lineages have been exported to north Africa since ~1850, including subtype 4a which dominates the epidemic in Egypt. We speculate on the causes of the historical intra-continental spread of genotype 4, including population movements during World War 2. © 2014 The Authors.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4162651/bin/mmc1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC4162651/bin/mmc2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC4162651/bin/mmc3.pdf
Authors & Co-Authors
Iles, James C.
United Kingdom, Oxford
University of Oxford
Raghwani, Jayna
United Kingdom, Oxford
University of Oxford
Harrison, Gabrielle L.Abby
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Pépin, Jacques
Canada, Sherbrooke
Université de Sherbrooke
Djoko, Cyrille Finyom
Cameroon, Yaounde
Global Viral Cameroon
Tamoufé, Ubald
United States, San Francisco
Metabiota, Inc.
LeBreton, Matthew
United States, San Francisco
Metabiota, Inc.
Schneider, Bradley S.
United States, San Francisco
Metabiota, Inc.
Fair, Joseph N.
United States, San Francisco
Metabiota, Inc.
Tshala, F.
Congo
Ministry of Defense
Kayembé, Patrick Kalambayi
Congo, Kinshasa
Kinshasa School of Public Health
Muyembe-Tamfum, Jean Jacques
Congo, Gombe
National Institute of Biomedical Research
Edidi-Basepeo, Samuel
Congo
National Aids Control Program
Wolfe, Nathan D.
United States, San Francisco
Metabiota, Inc.
United States, Palo Alto
Stanford University
Simmonds, Peter N.
United Kingdom, Midlothian
University of Edinburgh, Roslin Institute
Klenerman, Paul
United Kingdom, Oxford
Nuffield Department of Medicine
Pybus, Oliver George
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 72
Authors: 17
Affiliations: 12
Identifiers
Doi:
10.1016/j.virol.2014.07.006
ISSN:
00426822
e-ISSN:
10960341
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Congo
Egypt