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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Seroprevalence and distribution of Flaviviridae, Togaviridae, and Bunyaviridae arboviral infections in rural Cameroonian adults
American Journal of Tropical Medicine and Hygiene, Volume 74, No. 6, Year 2006
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Description
Arboviruses from the families Flaviviridae, Togaviridae, and Bunyaviridae are suspected to cause widespread morbidity in sub-Saharan African populations, but little research been done to document the burden and distribution of these pathogens. We tested serum samples from 256 Cameroonian adults from nine rural villages for the presence of Dengue-2 (DEN-2), West Nile (WN), Yellow fever (YF), Chikungunya (CHIK), O'nyong-nyong (ONN), Sindbis (SIN), and Tahyna (TAH) infection using standard plaque-reduction neutralization tests (PRNT). Of these samples, 12.5% were DEN-2 positive, 6.6% were WN positive, 26.9% were YF positive, 46.5% were CHIK seropositive, 47.7% were ONN positive, 7.8% were SIN positive, and 36.3% were TAH positive. DEN-2, YF, and CHIK seroprevalence rates were lower among individuals living in dwellings with grass or thatched roofs versus corrugated tin and in villages isolated from urban centers. Seroprevalence rates of YF and CHIK increased with age. These results suggest that inter-epidemic arboviral infection is common in central African populations. Copyright © 2006 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Kuniholm, Mark H.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Wolfe, Nathan D.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Huang, Claire Y.H.
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Mpoudi-Ngolé, Eitel
Cameroon, Yaounde
Ancien Bureau Pam Rue Ceper
Tamoufé, Ubald
Cameroon, Yaounde
Ancien Bureau Pam Rue Ceper
Burke, Donald S.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Gubler, Duane J.
United States, Honolulu
John A. Burns School of Medicine
Statistics
Citations: 114
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.4269/ajtmh.2006.74.1078
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases