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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
An international association between Helicobacter pylori infection and gastric cancer
The Lancet, Volume 341, No. 8857, Year 1993
Notification
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Description
Gastric infection with Helicobacter pylori seems to be a risk factor for gastric cancer. We have conducted a multicentre epidemiological study to investigate this relation further. Our study was designed to look at the relation between the prevalence of H pylori infection and gastric cancer rates in 17 populations from 13 countries, chosen to reflect the global range of gastric cancer incidence. In each centre, about 50 males and 50 females in each of the two age groups 25-34 years and 55-64 years were selected at random from the local population and provided blood samples. Serum samples were assayed for the presence of IgG antibodies to H pylori in a single laboratory. Prevalence rates of H pylori seropositivity were related to local gastric cancer incidence and mortality rates using linear regression. There was a statistically significant relation between the prevalence of seropositivity and cumulative rates (0-74 years) for both gastric cancer incidence and mortality with regression coefficients of 2·68 (p=0·001) and 1·79 (p=0·002), respectively. Our findings are consistent with an approximately six-fold increased risk of gastric cancer in populations with 100% H pylori infection compared with populations that have no infection. © 1993.
Authors & Co-Authors
Forman, David F.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Coleman, Michel P.
France, Lyon
Centre International de Recherche Sur le Cancer
de Backer, Guy G.
Belgium, Ghent
Universitair Ziekenhuis Gent
Elder, J.
United Kingdom, Keele
Keele University
Møller, H.
Denmark, Copenhagen
Danish Cancer Registry
Cayolla Da Motta, L.
Portugal, Lisbon
Escola Nacional de Saúde Pública, Universidade Nova de Lisboa
Roy, Pascal
France, Lyon
Centre International de Recherche Sur le Cancer
Abid, L.
Algeria, Algiers
Hôpital de Bologhine
Tjønneland, A. Marie
Denmark, Copenhagen
Danish Cancer Registry
Boeing, Heiner
Germany, Heidelberg
German Cancer Research Center
Haubrich, T.
Germany, Heidelberg
German Cancer Research Center
Wahrendorf, J.
Germany, Heidelberg
German Cancer Research Center
Manousos, O.
Greece, Heraklion
Heraklion University Hospital
Tulinius, Hrafn
Iceland, Reykjavik
Icelandic Cancer Society
Ogmundsdottir, H.
Iceland, Reykjavik
Icelandic Cancer Society
Palli, Domenico
Italy
Centro Per lo Studio e la Prevenzione Oncologica
Cipriani, Francesco
Italy
Centro Per lo Studio e la Prevenzione Oncologica
Fukao, A.
Japan, Sendai
Tohoku University
Tsugane, Shoichiro
Japan, Chuo-ku
National Cancer Center Research Institute
Miyajima, Y.
Poland
Yokote Health Centre
Zaton´ski, Witold A.
Poland, Warsaw
Maria Sklodowska-curie National Research Institute of Oncology
Tyczynski, J.
Poland, Warsaw
Maria Sklodowska-curie National Research Institute of Oncology
Calheiros, J.
Portugal, Porto
Universidade do Porto
Primic Zakelj, M.
Slovenia, Ljubljana
Onkološki Inštitut Ljubljana
Potocnik, M.
Slovenia, Ljubljana
Blood Transfusion Centre of Slovenia
Webb, Paul
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Knight, T.
United States, Minneapolis
University of Minnesota Twin Cities
Wilson, A.
United Kingdom, Keele
Keele University
Kaye, S.
United States, Minneapolis
University of Minnesota Twin Cities
Potter, John D.
United States, Minneapolis
University of Minnesota Twin Cities
Newell, Diane G.
United Kingdom, London
Public Health England
Hengels, K. J.
Unknown Affiliation
Statistics
Citations: 939
Authors: 32
Affiliations: 20
Identifiers
Doi:
10.1016/0140-6736(93)90938-D
ISSN:
01406736
Research Areas
Cancer
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Female