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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Oxidative stress, hematological and biochemical alterations in farmers exposed to pesticides
Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes, Volume 48, No. 12, Year 2013
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Description
In this study, a cohort of farmers from the Mateur region in the North of Tunisia, were interviewed and examined for the biochemical effects of pesticides. We studied their haematological profile, lipid parameters, serum markers of nephrotoxicity and hepatotoxicity. We also evaluated the activities of Butyrylcholinesterase (BChE), Acetylcholinesterase (AChE) and thiolactonase-paroxonase (PON). Moreover, lipid peroxidation and activities of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) were determined. The duration of pesticide use and the farmers' age were considered in the analysis. Our results revealed significant differences in some haematological parameters, in liver and kidney functions, in the lipidic status of the pesticide-exposed group. We also reported an increase in the index of incidence of cardiovascular risk in farmer populations. A significant decrease in AChE, BChE and PON levels was found among farmers. Lipid peroxidation, however, increased. The activities of SOD and CAT were remarkably elevated in farmer populations. There was a significant relation between changes in biological markers, the duration of pesticide use and the farmers' age. This study indicates that a long-term exposure to pesticides may play an important role in the development of vascular diseases via metabolic disorders of lipoproteins, lipid peroxidation and oxidative stress, inhibition of BChE and decrease in thiolactonase-PON levels. © 2013 Taylor and Francis Group, LLC.
Authors & Co-Authors
Tayeb, Wafa
Tunisia, Monastir
Laboratory of Biochemistry
Nadia, Koubaa
Tunisia, Monastir
Laboratory of Biochemistry
Nakbi, Amel
Tunisia, Monastir
Laboratory of Biochemistry
Ikbal, Chaieb
Tunisia, Sousse
Regional Research Centre in Horticulture and Organic Agriculture
Insaf, Tayeb
Tunisia, Monastir
Chu Fattouma-bourguiba
Kassab, Asma
Tunisia, Sousse
Hopital Farhat Hached Sousse
Hedi, Miled Abdel
Tunisia, Sousse
Hopital Farhat Hached Sousse
Hammami, M. B.
Tunisia, Monastir
Laboratory of Biochemistry
Statistics
Citations: 59
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1080/03601234.2013.824285
ISSN:
03601234
e-ISSN:
15324109
Research Areas
Environmental
Noncommunicable Diseases
Study Design
Cohort Study
Study Locations
Tunisia