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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Chikungunya and dengue fever among hospitalized febrile patients in Northern Tanzania
American Journal of Tropical Medicine and Hygiene, Volume 86, No. 1, Year 2012
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Description
Consecutive febrile admissions were enrolled at two hospitals in Moshi, Tanzania. Confirmed acute Chikungunya virus (CHIKV), Dengue virus (DENV), and flavivirus infection were defined as a positive polymerase chain reaction (PCR) result. Presumptive acute DENV infection was defined as a positive anti-DENV immunoglobulin M (IgM) enzyme-linked immunsorbent assay (ELISA) result, and prior flavivirus exposure was defined as a positive anti-DENV IgG ELISA result. Among 870 participants, PCR testing was performed on 700 (80.5%). Of these, 55 (7.9%) had confirmed acute CHIKV infection, whereas no participants had confirmed acute DENV or flavivirus infection. Anti- DENV IgM serologic testing was performed for 747 (85.9%) participants, and of these 71 (9.5%) had presumptive acute DENV infection. Anti-DENV IgG serologic testing was performed for 751 (86.3%) participants, and of these 80 (10.7%) had prior flavivirus exposure. CHIKV infection was more common among infants and children than adults and adolescents (odds ratio [OR] 1.9, P = 0.026) and among HIV-infected patients with severe immunosuppression (OR 10.5, P = 0.007). CHIKV infection is an important but unrecognized cause of febrile illness in northern Tanzania. DENV or other closely related flaviviruses are likely also circulating. Copyright © 2012 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Hertz, Julian T.
United States, Durham
Duke University Medical Center
Munishi, Oresto Michael
Tanzania, Moshi
Kilimanjaro Christian Medical Centre
Ooi, Eng Eong
Singapore, Singapore City
Duke-nus Medical School
Howe, Shiqin
Singapore, Singapore City
Duke-nus Medical School
Lim, Wen Yan
Singapore, Singapore City
Duke-nus Medical School
Chow, Angelia
Singapore, Singapore City
Duke-nus Medical School
Morrissey, Anne B.
United States, Durham
Duke University Medical Center
Bartlett, John A.
United States, Durham
Duke University Medical Center
Onyango, Jecinta J.
Tanzania, Moshi
Kilimanjaro Christian Medical Centre
Maro, Venance Phillip
Tanzania, Moshi
Kilimanjaro Christian Medical Centre
Kinabo, Grace Damas
Tanzania, Moshi
Kilimanjaro Christian Medical Centre
Saganda, Wilbrod
Tanzania
Mawenzi Regional Hospital
Gubler, Duane J.
Singapore, Singapore City
Duke-nus Medical School
Crump, John A.
United States, Durham
Duke University Medical Center
Statistics
Citations: 14
Authors: 14
Affiliations: 4
Identifiers
Doi:
10.4269/ajtmh.2012.11-0393
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Case-Control Study
Study Locations
Tanzania