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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Survey of air pollution in Cotonou, Benin - Air monitoring and biomarkers
Science of the Total Environment, Volume 358, No. 1-3, Year 2006
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Description
Exposure to genotoxic compounds present in ambient air has been studied in Cotonou, Benin, a city where two-stroke motorbikes are the major form of transportation and gasoline quality is poor. Personal monitoring and biomarkers were used to assess the exposure. Non-smoking taxi-moto drivers (city) and village residents were the study subjects. Benzene exposure was significantly higher in the city, as compared to the village (76.0 ± 26.8 μg/m 3 versus 3.4 ± 3.0, p = 0.0004). Urinary excretion of benzene and S-phenylmercapturic acid (S-PMA) were also highest in subjects living in the city, whereas 1-hydroxypyrene was not different. The level of total polycyclic aromatic hydrocarbons (PAHs), associated with particles, ranged from 76.21 to 103.23 in Cotonou versus 1.55 ng/m3 for the village. Determination of DNA damage in lymphocytes showed that subjects from the city had elevated number of lesions compared to subjects in the village in terms of bulky DNA adducts, 8-hydroxy-2′-deoxyguanosine and 5-methylcytosine, whereas DNA fragmentations analysed by alkaline gel electrophoresis was not different between the subjects. In conclusion, this study shows that air pollution is pronounced in Cotonou, Bénin and is associated with elevated levels of DNA damage in residents of the city compared to people living in a non-polluted rural village. © 2005 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Ayi-Fanou, Lucie
Benin, Cotonou
University of Abomey-calavi
Mobio, Théophile Amondo
France, Bordeaux
Université de Bordeaux
Creppy, Edmond Ekué
France, Bordeaux
Université de Bordeaux
Fayomi, Benjamin Eboum
Benin, Cotonou
University of Abomey-calavi
Fustoni, Silvia
Italy, Milan
Università Degli Studi Di Milano
Möller, Peter Lange
Denmark, Copenhagen
Københavns Universitet
Kyrtopoulos, Soterios
Greece, Athens
National Hellenic Research Foundation
Georgiades, Panos
Greece, Athens
National Hellenic Research Foundation
Loft, Steffen H.
Denmark, Copenhagen
Københavns Universitet
Sanni, Ambaliou
Benin, Cotonou
University of Abomey-calavi
Skov, Henrik
Denmark, Risø
National Institute of Environmental Research
Øvrebø, Steinar
Norway, Oslo
Statens Arbeidsmiljøinstitutt
Autrup, Herman N.
Denmark, Aarhus
Aarhus Universitet
Statistics
Citations: 78
Authors: 13
Affiliations: 8
Identifiers
Doi:
10.1016/j.scitotenv.2005.03.025
ISSN:
00489697
Research Areas
Environmental
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Benin