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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Lamivudine-induced red cell aplasia
Journal of Medical Microbiology, Volume 57, No. 8, Year 2008
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Description
Anaemia is frequent in patients with human immunodeficiency virus infection, and antiretroviral drugs have been implicated. Whilst therapy-induced anaemia is more readily attributed to zidovudine, lamivudine-associated, potentially life-threatening, pure red cell aplasia (PRCA) has been less recognized in the past and is only infrequently documented in the literature. We report on a patient suffering from what turned out to be lamivudine-induced PRCA who required 15 units of blood within 3 weeks before recovering swiftly following lamivudine (3TC) treatment withdrawal. As reviewed here, the nature of this condition is not well described in general, the onset appears to be variable and occurs at any CD4+ count, but rapid improvement after cessation of drug administration appears to be a consistent feature. © 2008 SGM.
Authors & Co-Authors
John, Melanie Anne A.
South Africa, Johannesburg
School of Pathology
Rhemtula, Yasin A.
South Africa, Johannesburg
University of the Witwatersrand
Menezes, Colin Nigel
South Africa, Johannesburg
School of Pathology
South Africa, Johannesburg
University of the Witwatersrand
Grobusch, Martín Peter
South Africa, Johannesburg
School of Pathology
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 24
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1099/jmm.0.47782-0
ISSN:
00222615
Research Areas
Health System And Policy