Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Expression of lung resistance protein and multidrug resistance-related protein (MRP1) in pediatric acute lymphoblastic leukemia
Journal of Oncology Pharmacy Practice, Volume 16, No. 3, Year 2010
Notification
URL copied to clipboard!
Description
Multidrug resistance (MDR) is a phenomenon by which cells become resistant to unrelated chemotherapeutic agents. The prognostic value that lung resistance protein (LRP) and multidrug resistance-related protein 1 (MRP1) have in the setting of pediatric acute lymphoblastic leukemia (ALL) is controversial. The aim of this study was to investigate the expression of LRP and MRP1 and effect on clinical outcome and prognosis. The mRNA expression of LRP and MRP1 were analyzed in leukemic blasts of 34 pediatric ALL patients. LRP and MRP1 mRNA expression were detected in 41.2% and 35.3%, respectively. Eleven (91.7%) of 12 patients without LRP achieved CR compared with 9 (50.0%) of 18 with LRP expression. Similarly, 11 (100%) of 11 patients without MRP1 expression achieved CR compared with 9 (47.4%) of 19 with MRP1 expression and higher LRP expression rate or MRP1 expression rate was present in patients with relapse than MDR genes negative patients. The expression of either of two genes was associated with poorer 2-year survival. Also, patients expressing both genes had poorer outcomes and had worse 2-year survival. We suggest that MDR expression affects complete remission and survival rates in ALL patients. Thus, diagnosis appears to provide prognostic information for pediatric ALL. © The Author(s), 2010.
Authors & Co-Authors
El-Sharnouby, Jehan A.
Egypt, Tanta
Faculty of Medicine
Abou El-Enein, Amani M.
Egypt, Tanta
Faculty of Medicine
El-Ghannam, Doaa M.
Egypt, Mansoura
Faculty of Medicine
El-Shanshory, Mohammed Ramadan
Egypt, Tanta
Faculty of Medicine
Hagag, Adel Abdelhaleim E.
Egypt, Tanta
Faculty of Medicine
Yahia, Sohier
Egypt, Mansoura
Faculty of Medicine
El-Ashry, Rasha Abd Elmalk
Egypt, Mansoura
Faculty of Medicine
Statistics
Citations: 24
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1177/1078155209351329
ISSN:
10781552