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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Sensitivity and specificity of clinician administered screening instruments in detecting depression among HIV-positive individuals in Uganda
AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, Volume 25, No. 10, Year 2013
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Description
Depressive disorders are highly prevalent in Africa where diseases such as HIV/AIDS are common. The aim of this study was to assess the validity of commonly used depression screening instruments in a setting characterized by low literacy, where patients may not be able to self-administer depression scales. We explored the validity of the Patient Health Questionaire-9 (PHQ-9), Centre for Epidemiological Surveys for Depression (CES-D), and the Kessler-10 (K-10), using the Mini International Neuropsychiatric Instrument (MINI) as a gold standard in 368 persons living with HIV/AIDS (PLWHA) in Uganda. The shorter versions of the K-10 and PHQ-9 were extracted to assess their performance in comparison to the longer versions. We used STATA 11.2 to analyze the data. The prevalence of a MINI defined depression in this patient sample was 17.4%. The three instruments all performed well, with areas under the curve (AUC) ranging from 0.82 to 0.96. The PHQ-9 showed the best performance characteristics with an AUC of 0.96, a sensitivity of 91.6%, and specificity 81.2%. The extracted versions performed more modestly. All three instruments showed good properties as screening tools; the PHQ-9 has particularly high sensitivity and specificity, and so can be considered useful for screening HIV-positive patients for depression. © Taylor and Francis.
Authors & Co-Authors
Akena, Dickens Howard
South Africa, Cape Town
University of Cape Town
Uganda, Kampala
Makerere University
Joska, John A.
South Africa, Cape Town
University of Cape Town
Obuku, Ekwaro A.
Uganda, Kampala
Joint Clinical Research Center Uganda
Stein, Dan J.
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 80
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1080/09540121.2013.764385
ISSN:
09540121
e-ISSN:
13600451
Research Areas
Health System And Policy
Infectious Diseases
Mental Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Uganda