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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Decreased immune activation in resistance to HIV-1 infection is associated with an elevated frequency of CD4+CD25+FOXP3+ Regulatory T Cells
Journal of Infectious Diseases, Volume 199, No. 9, Year 2009
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Description
Human immunodeficiency virus (HIV)-resistant commercial sex workers provide a unique opportunity to study correlates of protection associated with natural resistance to HIV infection. Emerging data from studies of these individuals and other uninfected individuals who have been exposed to HIV suggest that low levels ofimmuneactivationmaycontribute to protection against infection. In the present study, HIVresistant individuals were shown to have reduced frequencies of T cells expressing the activation marker CD69. They were also found to have elevated frequencies of regulatory T (Treg) cells, compared with HIV-negative control individuals. By controlling levels of T cell activation, Treg cells may contribute to HIV resistance by minimizing the pool of cells susceptible to infection. © 2009 by the Infectious Diseases Society of America.
Authors & Co-Authors
Card, Catherine M.
Canada
Departments of Medical Microbiology
McLaren, Paul J.
Canada
Departments of Medical Microbiology
Canada, Winnipeg
University of Manitoba
Wachihi, Charles
Kenya, Nairobi
University of Nairobi
Kimani, Joshua
Kenya, Nairobi
University of Nairobi
Plummer, Francis Allan
Canada
Departments of Medical Microbiology
Canada, Winnipeg
University of Manitoba
Canada, Ottawa
Public Health Agency of Canada
Fowke, Keith Raymond
Canada
Departments of Medical Microbiology
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
United States, Boston
Brigham and Women's Hospital
Statistics
Citations: 166
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1086/597801
ISSN:
00221899
Research Areas
Infectious Diseases