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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Association of high HIV-1 RNA levels and homozygosity at HLA class II DRB1 in adults coinfected with Mycobacterium tuberculosis in Harare, Zimbabwe
Human Immunology, Volume 63, No. 11, Year 2002
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Description
HIV-1 mRNA levels (virus load) were quantified for 191 pulmonary tuberculosis (TB) patients and 132 HIV-1 seropositive controls. Human leukocyte antigen (HLA) class I and II genes were typed for 188 patients and 121 HIV-1 seropositive controls. The mean log virus load was higher among cases than HIV-1 seropositive controls (p < 0.0001). Among the controls, mean log virus load was higher among males than females (p = 0.04). There was no association between virus load and homozygosity at HLA class I and II among the controls. In contrast, among the cases, HLA-DRB1 homozygosity was associated with high virus load (p = 0.008), conferring risk for rapid progression to AIDS, thus lending support to the heterozygote advantage hypothesis. The observed decreased virus load in HLA-DRB-1 heterozygotes may be due to a better control of M. tb. infection in the context of HIV-1 disease. © American Society for Histocompatibility and Immunogenetics, 2002. Published by Elsevier Science Inc.
Authors & Co-Authors
Zijenah, Lynn Sodai
Zimbabwe, Harare
Godfrey Huggins School of Medicine
Hartogensis, Wendy E.
United States, Oakland
Children's Hospital Oakland Research Institute
Katzenstein, David A.
United States, Stanford
Stanford Healthcare
Tobaiwa, Ocean
Unknown Affiliation
Mutswangwa, Junior
Zimbabwe, Harare
Godfrey Huggins School of Medicine
Mason, Peter R.
Zimbabwe, Harare
Godfrey Huggins School of Medicine
Louie, L.
United States, Oakland
Children's Hospital Oakland Research Institute
Statistics
Citations: 16
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/S0198-8859(02)00684-5
ISSN:
01988859
Research Areas
Infectious Diseases
Study Locations
Zimbabwe
Participants Gender
Female