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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Nucleotide sequence of mkaD, a virulence-associated gene of Salmonella typhimurium containing variable and constant regions
Gene, Volume 93, No. 1, Year 1990
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Description
We have identified the nucleotide (nt) sequence of mkaD, a virulence-associated gene of the Salmonella typhimurium virulence plasmid, pEX102. The gene shows 98% homology on nt sequence level to mkfA, a corresponding gene of the S. typhimurium virulence plasmid pIP1350. The few nt changes, however, caused more extensive changes on the amino-acid level. The differences between mkaD and mkfA were clustered in distinct variable regions rather than being randomly scattered along the sequence. A third salmonellar virulence plasmid, pLT2, contained an mkaD gene identical to that of pEX102. Our observation suggests that the conserved virulence determinant on the plasmids of Salmonellae may contain different alleles of the same gene. © 1990.
Authors & Co-Authors
Taira, Suvi
Tunisia, Tunis
National Public Health Institute
Rhen, Mikael
Tunisia, Tunis
National Public Health Institute
Statistics
Citations: 23
Authors: 2
Affiliations: 1
Identifiers
Doi:
10.1016/0378-1119(90)90150-P
ISSN:
03781119
Research Areas
Genetics And Genomics
Infectious Diseases