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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genomic imbalances in Schistosoma-associated and non-Schistosoma-associated bladder carcinoma. An array comparative genomic hybridization analysis
Cancer Genetics and Cytogenetics, Volume 177, No. 1, Year 2007
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Description
Carcinoma of the urinary bladder is the most common malignancy in many tropical and subtropical countries due to endemic infection by Schistosoma hematobium (bilharzia). In the current study, we performed a high-resolution analysis of gene copy number amplifications using array comparative genomic hybridization to compare DNA copy number changes in pools of Schistosoma-associated (SA) and non-Schistosoma-associated (NSA) bladder cancer (BC). Many DNA copy number changes were detected in all studies, with multiple gains and losses of genetic material. The most frequent alterations were gains on 5p15.2∼p15.33, 8q13.1, and 11q13, and losses on 8p21.3∼p22 and 22q13. Even when SA pools showed no Schistosoma-specific gene copy number profiling as compared to NSA pools, some genes seemed to be gained (ELN on 7q11.23) and some lost (PRKAG3 on 2q35 and PRDM6 on 5q23.2) in SA-SCC. The following genes were gained in all histopathologic categories: SRC (20q11.23), CEBPB (20q13.13), and GPR9 (Xq13.1). Our study did not provide clear evidence of differences in carcinogenesis of SA-BC and NSA-BC. © 2007 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Armengol, Gemma
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Finland, Helsinki
Haartman Institute
Eissa, Saad Sayed
Egypt, Giza
National Cancer Institute
Lozano, J. J.
Spain, Barcelona
Centro de Regulacion Genomica, Barcelona
Shoman, Soheir H.
Egypt, Giza
National Cancer Institute
Sumoy, Lauro
Spain, Barcelona
Centro de Regulacion Genomica, Barcelona
Caballín, María Rosa
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Knuutila, Sakari
Finland, Helsinki
Haartman Institute
Statistics
Citations: 21
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/j.cancergencyto.2007.04.010
ISSN:
01654608
Research Areas
Cancer
Genetics And Genomics